Hepatic Function and Halothane

Joseph, Samuel I.

doi:10.1097/00000542-196401000-00033

Cited by 3 publications

(3 citation statements)

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“…percentage retention at the one-week and three-week post-exposure periods, but the figures do not differ significantly from those in Table I. al., 1958;Burnap et al, 1958;Carson et al, 1959;Griffiths and Ozguc, 1964;Joseph, 1964;Keeri-SzAt6, 1965), Retention (± S.D.) after in dogs (Brindle et al, 1957), in sheep (Hull and Reilly, 1968), res and in calves (Middleton et al, 1966 (Combes and Stakelum, 1962) to support the view that the 5 ±3 6±3 removal of B.S.P.…”

Section: Isolated Liver Perfusionsmentioning

confidence: 85%

Multiple Halothane Exposure and Hepatic Bromsulphthalein Clearance

Biebuyck

Saunders

Harrison

et al. 1971

Survey of Anesthesiology

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Section: Isolated Liver Perfusionsmentioning

confidence: 85%

Multiple Halothane Exposure and Hepatic Bromsulphthalein Clearance

Biebuyck

Saunders

Harrison

et al. 1971

Survey of Anesthesiology

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“…have previously been reported in (Brindle al., 1957; values v. control (Student's Virtue et al, 1958;Burnap et al, 1958;Carson et al, 1959;Griffiths and Ozguc, 1964;Joseph, 1964;Keeri-SzAt6, 1965), Retention (± S.D.) after in dogs (Brindle et al, 1957), in sheep (Hull and Reilly, 1968), res and in calves (Middleton et al, 1966).…”

Section: Isolated Liver Perfusionsmentioning

confidence: 99%

Multiple Halothane Exposure and Hepatic Bromsulphthalein Clearance

Biebuyck¹,

Saunders²,

Harrison³

et al. 1970

BMJ

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Multiple exposures to halothane have been shown to have delayed effects on bromsulphthalein (B.S.P.) clearance. Rats were exposed to repeated halothane anaesthetics, and their livers were subsequently isolated and perfused. B.S.P. retention in the perfusate of these isolated livers was greatly increased one to three weeks after the last halothane exposure. In similarly pretreated animals at the same time period the B.S.P.-glutathione conjugating enzyme activity in homogenates of the livers was found to be depressed. These findings did not occur after multiple diethyl ether exposures or following a single exposure to halothane.

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“…At the present time there is no anaesthetic drug in common use which will cause liver necrosis in both man and the experimental animal Investigations of the liver function of patients before and after major operations performed under modern anaesthetic methods have failed to reveal any deterioration beyond that normally expected after major surgery (Sadove and Wallace, 1962). The degree of postoperative liver dysfunction appears to be uninfluenced by the type of anaesthesia used (Little and Given, 1964;Joseph, 1964). Retrospective studies of the incidence of postoperative liver failure have shown it to be relatively unaltered irrespective of the changes which have occurred in anaesthetic methods (Dawson et al, 1963;Mazzia, 1963;Keeri-Szant6 and Lafleur, 1963;Wilson, Tarrow and Garvin, 1964;Allen and Metcalf, 1964;Slater et al, 1964;Mushin et al, 1964;Reichmann and Wohlgemuth, 1964;Collins and Fabian, 1964;Henderson and Gordon, 1964).…”

mentioning

confidence: 99%

Liver Injury in the Surgical Patient: A Critical Review

Johnstone¹

1964

British Journal of Anaesthesia

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This is a critical review of the reports of postoperative jaundice and liver necrosis that have been published during the past twenty-five years. Postoperative liver damage has the following causes: transmitted, provoked, or coincidental viral infections; acute sepsis and septicaemic states; blood transfusion; widespread vasoconstriction with hypotension lasting more than twenty-four hours; allergic reactions to antigenic substances; alleged "hypersensitivity" to drugs to which antibodies cannot be identified; the direct effects of certain therapeutic agents on the liver; surgical trauma to the liver and its appendages; and postoperative pancreatitis. Several of these factors may operate simultaneously in the patient recovering from a surgical operation and in these circumstances it is impossible to dissociate one particular cause from the others. The syndromes of viral hepatitis and drug "hypersensitivity" are indistinguishable. Both are associated with fever, skin rashes, leucopenia, arthralgia, cholestatic jaundice, and liver necrosis with a mononuclear infiltration of the liver. Both are peculiar to man and the time interval between the exposure to risk and the appearance of jaundice varies from less than seven days to more than three months. The development of immunity to the one or desensitization from the other is not universal. There is no inhalational anaesthetic agent in common use which comes within the definitions of directly or indirectly hepatotoxic substances. The pharmacological methods of screening inhalational anaesthetic agents for hepatotoxidty have always been reliable and there is no reason to doubt their efficacy at the present time.

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Hepatic Function and Halothane

Cited by 3 publications

References 0 publications

Multiple Halothane Exposure and Hepatic Bromsulphthalein Clearance

Multiple Halothane Exposure and Hepatic Bromsulphthalein Clearance

Multiple Halothane Exposure and Hepatic Bromsulphthalein Clearance

Liver Injury in the Surgical Patient: A Critical Review

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