Hepatic Fibrosis: Prospective Comparison of MR Elastography and US Shear-Wave Elastography for Evaluation

Yoon, Jeong Hee; Lee, Jeong Min; Joo, Ijin; Lee, Eun Sun; Sohn, Ji Young; Jang, Suk Ki; Lee, Kyuho; Han, Joon Koo; Choi, Byung Ihn

doi:10.1148/radiol.14132000

Cited by 153 publications

(139 citation statements)

References 60 publications

(72 reference statements)

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“…MRE can be easily added to standard abdominal MRI protocols, promising value added in staging liver cirrhosis. One study showed that MRE and SSI results moderately correlated with liver cirrhosis values, though MRE measurements tended to be more reliable than US elastography [56] . MRE has many advantages: (1) it can exam the whole liver, with a lower sampling error than with a biopsy or other imaging modalities; (2) good diagnostic accuracy; and (3) the results are not influenced by hepatic steatosis, obesity, and ascites.…”

Section: Mrimentioning

confidence: 99%

Prediction of liver cirrhosis, using diagnostic imaging tools

Yeom

Lee

Hoon

et al. 2015

WJH

107

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Early diagnosis of liver cirrhosis is important. Ultrasoundguided liver biopsy is the gold standard for diagnosis of liver cirrhosis. However, its invasiveness and sampling bias limit the applicability of the method. Basic imaging for the diagnosis of liver cirrhosis has developed over the last few decades, enabling early detection of morphological changes of the liver by ultrasonography (US), computed tomography, and magnetic resonance imaging (MRI). They are also accurate diagnostic methods for advanced liver cirrhosis, for which early diagnosis is difficult. There are a number of ways to compensate for this difficulty, including texture analysis to more closely identify the homogeneity of hepatic parenchyma, elastography to measure the stiffness and elasticity of the liver, and perfusion studies to determine the blood flow volume, transit time, and velocity. Amongst these methods, elastography using US and MRI was found to be slightly easier, faster, and able to provide an accurate diagnosis. Early diagnosis of liver cirrhosis using MRI or US elastography is therefore a realistic alternative, but further research is still needed.

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Section: Mrimentioning

confidence: 99%

Prediction of liver cirrhosis, using diagnostic imaging tools

Yeom

Lee

Hoon

et al. 2015

WJH

107

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“…54 -66 However, only a limited number of clinical studies have compared the discriminative abilities of MRE and ultrasound-based elastography for staging hepatic fibrosis. [58][59][60]66 Two of those revealed the superior ability of MRE to Fibroscan μ for distinguishing stages of hepatic fibrosis, 58,60 and the others revealed the similar diagnostic performance of MRE, Fibroscan μ , and SWE for staging hepatic fibrosis. 59,66 Consequently, it might be concluded that the discriminative ability of MRE for staging hepatic fibrosis is equivalent or superior to that of ultrasound-based elastography.…”

Section: Discussionmentioning

confidence: 93%

Validity and Reliability of Magnetic Resonance Elastography for Staging Hepatic Fibrosis in Patients with Chronic Hepatitis B

et al. 2015

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Purpose: We evaluated the validity and reliability of magnetic resonance elastography (MRE) for staging hepatic fibrosis in patients with chronic hepatitis B.Methods: The study included 73 patients with chronic hepatitis B and confirmed stages of pathological fibrosis. Two radiologists measured liver stiffness using MRE in all cases. We compared the area under the receiver operating characteristic (ROC) curve (Az) for distinguishing stages of fibrosis compared with MRE liver stiffness measurements and serum fibrosis markers. We used intraclass correlation coefficients to analyze interobserver agreement for measurements of liver stiffness and 2 one-sided t-tests to test the equivalence of the measurements by the 2 observers.Results: ROC analyses revealed the significantly superior discrimination abilities of MRE for liver fibrosis staging (Az = 0.945 to 0.978 [Observer 1] and 0.936 to 0.967 [Observer 2]) to those of serum fibrosis markers (0.491 to 0.742) for both observers (P < 0.0004). The intraclass correlation coefficient between the 2 observers was excellent (µ = 0.971), and the measurements of liver stiffness by the 2 observers were statistically equivalent within a 0.1-kPa difference (P = 0.0157) Conclusion: MRE is a valid and reliable technique for discriminating the stage of hepatic fibrosis in patients with chronic hepatitis B.

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“…Point shear-wave elastrography is similar to FibroScan but requires more expertise, is less well validated, and is not a point of care test ( 17,18,30 ). 2D MRE has the advantage of examining a larger area of the liver, is operator independent, and has excellent accuracy (17)(18)(19)29,31 ). Given the heterogeneity of hepatic fi brosis, particularly in more severe stages, MR elastography can more fully evaluate fi brosis as compared with the limited sampling of ultrasound FibroScan and even liver biopsy.…”

Section: Discussionmentioning

confidence: 99%