Hepatic epithelioid haemangioendothelioma: is transplantation the only treatment option?

Abstract

LR and OLT achieve comparable results in the treatment of HEH. LR is appropriate for patients with resectable disease and favourable prognostic factors. OLT is appropriate for patients with unresectable disease and possibly those with unfavourable prognostic factors. Metastases may not be a contraindication to surgical treatment.

Hepatic Epithelioid Hemangioendothelioma – a Rare Tumor and Diagnostic Dilemma

“…Patients with multiple nodules have a worse prognosis. In contrast, the prognosis is not affected by the presence of extra-hepatic metastases (10). Worse overall survival has been noted in patients with HEHE over 10 cm in diameter and in older patients.…”

Management of synchronous vascular and ductal anomalies in living donor liver transplantation for hepatic epithelioid hemangioendothelioma

“…This is a rare, low-grade vascular malignancy whose therapeutic algorithm is far from standardized. 1,2 As demonstrated by different authors, [3][4][5][6] liver transplantation is a valuable treatment for hepatic epithelioid hemangioendothelioma, even in cases of extrahepatic metastasis. In our case, the 26-year-old donor and the 26-year-old recipient were twins (brother and sister, respectively).…”

Current status of the organ replacement approach for malignancies and an overture for organ bioengineering and regenerative medicine

“…68,70 Recently, Grotz et al stated that patients with tumor size ≤ 10 cm, number up to 10, and extent of hepatic involvement up to 4 segments, are candidates for liver resection rather than LT and further investigations are warranted to clearly define the role of each surgical treatment. 71 In the pediatric population, LT remains a good treatment modality in patients with unresectable HEHE, although the prognoses may not be as promising as other primary liver tumors, i.e., hepatoblastoma and HCC. 72 The data on LT for primary sarcoma are disappointing.…”