Hepatic encephalopathy: definition, etiology, pathogenesis factors, clinical picture, diagnostic and treatment methods

Tsimmerman, Y. S.

doi:10.33149/vkp.2018.01.07

Cited by 2 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…При цьому динаміка перебігу залежить від перебігу ХП [7]. Диференційна діагностика панкреатичної енцефалопатії утруднюється при поєднаному перебігу хронічного панкреатиту із захворюваннями гепатобіліарної системи [13]. Gastroenterologìa, ISSN 2308-2097 (print), ISSN 2518-7880 (online)…”

Section: огляди та лекції / Reviews and Lecturesunclassified

Chronic pancreatitis: about some complications and features of their pathogenesis and course

Hristich

Hontsariuk

2022

GASTRO

View full text Add to dashboard Cite

The review article provides up-to-date information on the complications of pancreatitis that are important for the tactics and strategy of patient management both at the inpatient and outpatient stages of observation. The purpose of the review was to emphasize the importance of complications for the course and life of patients with chronic pancreatitis. The authors draw the attention of internists to the course of such complications as pseudocysts, cysts, fistulas, thrombohemorrhagic, cholestatic syndromes, compression syndrome of adjacent organs, pancreatic encephalopathy (acute and chronic). The symptomatology of complications of chronic pancreatitis is discussed in detail, which is very important for differential diagnosis with the corresponding diseases. Such complications include the formation of erosive and ulcerative lesions, varicose veins of the esophagus and bleeding from varicose veins of the esophagus and stomach, portal hypertension syndrome with pancreatic ascites and chronic pancreatic encephalopathy, idiopathic non-cirrhotic portal hypertension, pancreatic cancer. The authors emphasize the need to analyze the corresponding symptoms, indicating the possibility of complications, negative consequences with each recurrence or exacerbation of chronic pancreatitis, since it concerns the prognosis and life of the patient.

show abstract

Section: огляди та лекції / Reviews and Lecturesunclassified

Chronic pancreatitis: about some complications and features of their pathogenesis and course

Hristich

Hontsariuk

2022

GASTRO

View full text Add to dashboard Cite

show abstract

“…If the detoxifying function of the liver is reduced, the conversion of ammonia into urea is hindered and alternative metabolic pathways for this purpose are activated in the muscular system, astrocytes of the central nervous system, and kidneys [8][9][10]. Skeletal muscle tissue and nervous tissue are the main ammonia detoxifi ers [11].…”

Section: Excreted Urea Consists Of "Ammonia" Nitrogen and Aspartic Ac...mentioning

confidence: 99%

Russian Consensus on “Hyperammonemia in Adults”: The 2021 Version (in English)

Лазебник

Голованова

Алексеенко

et al. 2022

jour

View full text Add to dashboard Cite

Hyperammonemia is an acute or chronic intoxication with ammonia and ammonium associated with elevated ammonia levels in serum due to either its increased production and/or decreased detoxification. Hyperammonemia can result from a variety of causes and clinically presents with unspecific signs and symptoms, including asthenia, encephalopathy, liver steatosis or fibrosis, and sarcopenia. With impaired liver function, hyperammonemia most frequently manifests in (micro)encephalopathy. Thus in case of unexpect change in mental status hyperammonemia must be excluded as fast as possible. An express method of photometric assay is informative enough to determine the ammonia levels. The following hyperammonemia classification is proposed: a) by ammonia levels (normal level: ≤ 60 μmol/L; mild (Grade 1): ≤ 100 μmol/L; moderate (Grade 2): ≤ 200 μmol/L; and severe (Grade 3): > 200 μmol/L); b) by etiopathogenesis (hereditary (congenital), functional (physiological), acquired (hepatic, extrahepatic, mixed)); c) by clinical presentation (transient, recurrent or persistent, constant (stable, without treatment), covert). Treatment for hyperammonemia is aimed at treating the primary disease and includes a diet that is restricted in animal protein but contains sufficient vegetable protein, limited physical activities, and use of intestinal non-absorbable antibiotics (rifaximin- alpha) as well as pre- and probiotics. L-ornithine- L-aspartate (LOLA) is a baseline therapeutic product administered in a number of scenarios to correct the level of hyperammonemia.

show abstract

Hepatic encephalopathy: definition, etiology, pathogenesis factors, clinical picture, diagnostic and treatment methods

Cited by 2 publications

References 5 publications

Chronic pancreatitis: about some complications and features of their pathogenesis and course

Chronic pancreatitis: about some complications and features of their pathogenesis and course

Russian Consensus on “Hyperammonemia in Adults”: The 2021 Version (in English)

Contact Info

Product

Resources

About