Chronic pancreatitis: about some complications and features of their pathogenesis and course

Abstract

The review article provides up-to-date information on the complications of pancreatitis that are important for the tactics and strategy of patient management both at the inpatient and outpatient stages of observation. The purpose of the review was to emphasize the importance of complications for the course and life of patients with chronic pancreatitis. The authors draw the attention of internists to the course of such complications as pseudocysts, cysts, fistulas, thrombohemorrhagic, cholestatic syndromes, compression syndrome of adjacent organs, pancreatic encephalopathy (acute and chronic). The symptomatology of complications of chronic pancreatitis is discussed in detail, which is very important for differential diagnosis with the corresponding diseases. Such complications include the formation of erosive and ulcerative lesions, varicose veins of the esophagus and bleeding from varicose veins of the esophagus and stomach, portal hypertension syndrome with pancreatic ascites and chronic pancreatic encephalopathy, idio­pathic non-cirrhotic portal hypertension, pancreatic cancer. The authors emphasize the need to analyze the corresponding symptoms, indicating the possibility of complications, negative consequences with each recurrence or exacerbation of chronic pancreatitis, since it concerns the prognosis and life of the patient.

Oxidative and nitrosative stress — the leading mechanisms of chronic pancreatitis and chronic obstructive pulmonary disease interaction and inducers of their progression

“…The LPO initiation is accompanied by damage to the lipid bilayer of membranes not only in the pancreas, but also in the epithelium of the bronchi and alveolocytes in the lungs in the comorbid course of CP and COPD [6,8,10,24]. Confirmation is our data on the maximum increase in the content of MA, IDB, CD, and KD & CT in CP and COPD (p < 0.05) patients among the comparison groups, which probably differed from the indicators in groups with both CP and COPD (p < 0.05) isolated course.…”

“…Numerous studies have been devoted to studying the intensity of lipid peroxidation (LPO) processes and the state of antioxidant defense factors (AOD) in patients with inflammatory pathology of the digestive system, pulmonological pathology [1][2][3], since the intensification of oxidative (OS) and nitrosative stress (NS) can contribute both to the development of diseases, significantly affect their course, and contribute to their progression with the development of functional organ failure [4][5][6][7][8][9][10][11][12]. Chronic pancreatitis (CP) is the pathology characterized by the OS and NS high level, especially during exacerbation of the inflammatory process [3, Gastroenterologìa, ISSN 2308-2097 (print), ISSN 2518-7880 (online) Патологія підшлункової залози / Pancreatic Pathology 4, 7,[12][13][14][15].…”