Hepatic CT enhancement: effect of the rate and volume of contrast medium injection in an animal model

Garcia, P.; Génin, G.; Bret, Patrice M.; Bonaldi, V. M.; Reinhold, Caroline; Atri, Mostafa

doi:10.1007/s002619900572

Cited by 34 publications

(17 citation statements)

References 14 publications

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“…However, for a given increase in injection rate, the rate of increase in the magnitude of aortic contrast enhancement is substantially greater than that of the liver (Fig. 5) [22][23][24]. The magnitude of peak aortic enhancement increases almost linearly with injection rate increases, but the peak hepatic enhancement increases much more gradually and is apparent only at relatively low injection rates (< 3 mL/s).…”

Section: Injection Ratementioning

confidence: 88%

Scan and contrast administration principles of MDCT

Bae

Heiken

2005

Eur Radiol Suppl

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Because of its fast scan speed, multi-detector row CT (MDCT) imposes a challenge to optimization of contrast enhancement and scan timing. However, when this challenge is overcome with the use of precisely designed protocols, MDCT provides us with an opportunity to use contrast medium more efficiently and flexibly than with single-detector row CT (SDCT). To fully achieve the benefits of MDCT, it is crucial for radiologists and technologists to 1) understand the factors that determine contrast enhancement and scan timing for MDCT, and 2) identify the required modifications in protocol design to optimize contrast enhancement for MDCT. Clinical considerations for CTA and hepatic imaging are described in this article.

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Section: Injection Ratementioning

confidence: 88%

Scan and contrast administration principles of MDCT

Bae

Heiken

2005

Eur Radiol Suppl

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“…It is expected that the use of bolus chaser also allows CM volume reduction in MSCT coronary angiography [16,17,18].…”

Section: Introductionmentioning

confidence: 99%

Non-invasive 16-row multislice CT coronary angiography: usefulness of saline chaser

et al. 2003

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The aim of this study was to investigate the usefulness of saline chaser in 16-row multislice CT (16-MSCT) coronary angiography. Forty-two patients were divided into two groups for contrast material (CM) administration: group 1 (140 ml at 4 ml/s) and group 2 (100 ml at 4 ml/s followed by 40 ml of saline chaser at 4 ml/s). All patients underwent retrospectively ECG-gated 16-MSCT coronary angiography. The attenuation at the origin coronary vessels was assessed. Three regions of interest (ROIs) were drawn throughout the data set: (a) ascending aorta (ROI 1); (b) descending aorta (ROI 2); and (c) pulmonary artery (ROI 3). The attenuation in the superior vena cava was recorded (ROI 4). The average attenuation and the slope were calculated in each ROI and differences were assessed with a Student's t test. The average attenuation in the coronary vessels was not significantly different in the two groups. The average attenuations in ROI 1 were 325 and 327 HU, in ROI 2 were 328 and 329 HU and in ROI 3 were 357 and 320 HU, for groups 1 and 2, respectively (p>0.05). The slopes in ROI 1 were -0.2 and 1.1, in ROI 2 were 2.8 and 2.1 (p>0.05) and in ROI 3 were 3.9 and -9.0 (p<0.05), for groups 1 and 2, respectively. The average attenuations in ROI 4 were 927 and 643 HU (p<0.05), for groups 1 and 2, respectively. One hundred milliliters of CM with 40 ml of saline chaser provides the same attenuation as 140 ml of CM (35% less) with decreased hyper-attenuation in the superior vena cava.

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“…Two major factors cause different levels of concentration gradients: the injection rate as dem- onstrated in several studies [21 -23] and the concentration of the administrated contrast agent, such as investigated in our study. The discussion about the adequate iodine dose and contrast agent concentration for optimal aortic and hepatic enhancement during abdominal CT is still controversial and several -partially different statements have been published in previous studies [24,25]. How far the injection rate plays another role with the faster acquisition possibilities of multi-detector row CT compared to single-detector row CT remains open.…”

Section: Discussionmentioning

confidence: 94%

Multi-detector Row CT: Effect of Iodine Dose Reduction on Hepatic and Vascular Enhancement

2004

Rofo Fortschr Geb Rontgenstr N

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Hepatic CT enhancement: effect of the rate and volume of contrast medium injection in an animal model

Cited by 34 publications

References 14 publications

Scan and contrast administration principles of MDCT

Scan and contrast administration principles of MDCT

Non-invasive 16-row multislice CT coronary angiography: usefulness of saline chaser

Multi-detector Row CT: Effect of Iodine Dose Reduction on Hepatic and Vascular Enhancement

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