Hepatic contribution to circulating cytokine levels in severe acute pancreatitis in rats

A Priori Dietary Ω‐3 Lipid Supplementation Results in Local Pancreatic Macrophage and Pulmonary Inflammatory Response Attenuation in a Model of Experimental Acute Edematous Pancreatitis (AEP)

“…In fact, the liver was recently shown to contribute to the elevation in serum IL-6 during AP. 5 Hepatic cytokine elaboration can also have downstream effects on alveolar macrophages that cause pulmonary dysfunction. 5 This inflammatory cascade beginning at the level of the gastrointestinal tract and ending in the lung has been referred to as the "gut-hepatic-pulmonary axis" and may explain how pancreatitis rapidly progresses to pulmonary dysfunction.…”

“…5 Hepatic cytokine elaboration can also have downstream effects on alveolar macrophages that cause pulmonary dysfunction. 5 This inflammatory cascade beginning at the level of the gastrointestinal tract and ending in the lung has been referred to as the "gut-hepatic-pulmonary axis" and may explain how pancreatitis rapidly progresses to pulmonary dysfunction. Leukocyte respiratory burst (LRB) is a common test used to measure the inflammatory response of the lungs to an inflammatory insult anywhere in the body.…”