Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36

Nergiz-Unal, Reyhan; Ulug, Elif; Kisioglu, Betul; Tamer, Funda; Bodur, Mahmut; Yalcimin, Hacer; Yürük, Armağan Aytuğ

doi:10.1016/j.nut.2020.110954

Cited by 13 publications

(11 citation statements)

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“…The HDL-C/LDL-C ratio in mice fed with lard was significantly lower than those fed with soybean oil and lard and soybean oil mixture. Numerous studies have reported that lard, rich in SFA, increased serum TC and LDL-C content, especially [40,41]. Hayes KC et al [42] found that serum HDL-C increased when serum LDL-C reduced with SFA intake, consistent with our present results.…”

Section: Discussionsupporting

confidence: 92%

A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

Yan

Liu

et al. 2022

Nutrients

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Dietary habit is highly related to nonalcoholic fatty liver disease (NAFLD). Low-fat–high-carbohydrate (LFHC) diets could induce lean NAFLD in Asians. Previously, we found that a lard and soybean oil mixture reduced fat accumulation with a medium-fat diet; therefore, in this study, we evaluated the effect of a lard and soybean oil mixture (LFHC diet) on NAFLD and its underlying mechanisms. Mice in groups were fed with lard, soybean oil, or a lard and soybean oil mixture—an LFHC diet—separately. Our results showed that mixed oil significantly inhibited serum triglyceride, liver triglyceride, serum free fatty acids (FFAs), and liver FFAs compared with soybean oil or lard, and we found fewer inflammatory cells in mice fed with mixed oil. RNA-seq results indicate that mixed oil reduced FFAs transportation into the liver via decreasing liver fatty acid-binding protein 2 expression, inhibited oxidative phosphorylation via tumor necrosis factor receptor superfamily member 6 downregulation, and alleviated inflammation via downregulating inflammatory cytokine. The liquid chromatography–mass spectrometry results showed that the mixed oil promoted bile acid conjugated with taurine and glycine, thus activating G-protein-coupled bile acid receptor 1 for improved lipids metabolism. In conclusion, the lard and soybean oil mixture alleviated NAFLD.

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Section: Discussionsupporting

confidence: 92%

A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

Yan

Liu

et al. 2022

Nutrients

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“…5B). After high-fat intake, the level of cholesterol in the liver of mice increased, accompanied by an increase in the expression of CD36 , which plays an important role in maintaining cholesterol balance in the body (Nergiz-Unal et al , 2020). CD36 is able to take up FAs through a dynamic palmitoyl-regulated endocytic pathway(Hao et al , 2020).…”

Section: Resultsmentioning

confidence: 99%

The transcription factor RXRA regulates lipid metabolism in duck myoblasts by the CD36 network

Pan

et al. 2022

Preprint

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Lipid metabolism is a highly complex metabolic process regulated at multiple levels. RXRA is a well-characterized factor that regulates lipid metabolism. To explore the function and mechanism of the transcription factor RXRA in myoblasts, and to further explore the key factors that RXRA regulates the target gene CD36 signaling network to regulate lipid metabolism. We found that the transcription factor RXRA inhibited the accumulation of triglycerides (TGs), cholesterol (CHOL) and non-esterified fatty acids (NEFA) in CS2 cells by regulating CD36 as well as the fatty acid beta oxidation pathway. CD36 functions similar to RXRA in myoblasts. CD36 overexpression reduced the levels of TGs, CHOL, NEFAs and saturated fatty acids (SFAs) in these cells, while CD36 knockout increased the levels of TGs, CHOL, NEFAs, SFAs and monounsaturated fatty acids (MUPAs) in these cells. GRB2, MAP1B, SLC38A1, SLC4A7, NCOA3, PKIA, MOB2, SAA2 and RXRA are involved in the CD36 promotion of lipid efflux through lipid metabolism, endocytosis and amino acid metabolism. Considering these results, we propose that RXRA regulates lipid metabolism in myoblasts by regulating the CD36 signaling network.

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“…Expression levels of these genes in the liver are upregulated in NAFLD model, suggesting a crucial role of lipid synthesis in hepatic steatosis ( Fu et al, 2018 ; Zhang et al, 2020b b). As a key gene responsible for regulating lipid uptake in hepatocytes, the expression level of CD36 is closely related to the pathological process of fatty liver and insulin resistance ( Nergiz-Unal et al, 2020 ). Previous study had shown that CD36 transports fatty acids into cells through FATP , thereby promoting the formation and accumulation of intracellular triglycerides ( Nergiz-Unal et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…As a key gene responsible for regulating lipid uptake in hepatocytes, the expression level of CD36 is closely related to the pathological process of fatty liver and insulin resistance ( Nergiz-Unal et al, 2020 ). Previous study had shown that CD36 transports fatty acids into cells through FATP , thereby promoting the formation and accumulation of intracellular triglycerides ( Nergiz-Unal et al, 2020 ). In this study, P. acidilactici FZU106 intervention prevented the uptake of fatty acids by decreasing the mRNA level of CD36 in HFD-fed rats.…”

Section: Discussionmentioning

confidence: 99%

Pediococcus acidilactici FZU106 alleviates high-fat diet-induced lipid metabolism disorder in association with the modulation of intestinal microbiota in hyperlipidemic rats

Zhang

Guo

Chen

et al. 2022

Current Research in Food Science

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Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36

Cited by 13 publications

References 50 publications

A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

A Lard and Soybean Oil Mixture Alleviates Low-Fat–High-Carbohydrate Diet-Induced Nonalcoholic Fatty Liver Disease in Mice

The transcription factor RXRA regulates lipid metabolism in duck myoblasts by the CD36 network

Pediococcus acidilactici FZU106 alleviates high-fat diet-induced lipid metabolism disorder in association with the modulation of intestinal microbiota in hyperlipidemic rats

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