Hepatic Arterial Doppler Sonography in Patients with Cirrhosis and Controls: Observer and Equipment Variability with use of the Ultrasonic Contrast Agent SHU 508A

Hübner, Georg; Steudel, Norbert; Reissmann, A.; Kuhne, I.; Kleber, Gerhardt; Schärff, K; We, Fleig

doi:10.1055/s-2005-858103

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…Doppler assessment is a repeatable method for measuring hepatic blood flow, with stable intra-observer variability [ 12 ]. However, inter-observer variability of Doppler measurements has been reported to range from 0% to 10% [ 13 , 14 ]. In the usual clinical setting, postoperative serial follow-up Doppler examinations of recipients of LT are not performed by one examiner, and therefore, Doppler parameters before and after administering USCA could be affected by inter-observer variability.…”

Section: Discussionmentioning

confidence: 99%

Influence of ultrasound contrast agents on spectral Doppler analysis in recipients of liver transplantation

et al. 2017

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Background/AimsClinical validation is required to determine whether Doppler measurements are comparable before and after administering ultrasound contrast agent (USCA). The purpose of this study is to explore whether the use of USCA affects spectral Doppler analysis in recipients of liver transplantation (LT).MethodsFor this study, 36 patients were examined using Doppler ultrasonography (US) along with a contrast-enhanced US for surveillance of vascular complications after LT. The following spectral Doppler US parameters were measured before and after administration of USCA: peak systolic velocity, end-diastolic velocity, resistive index, and systolic acceleration time of the graft hepatic artery; peak flow velocity of the graft portal vein; and peak flow velocity and venous pulsatility index of the graft hepatic vein.ResultsThe mean peak systolic and end-diastolic velocities of the hepatic artery and the peak flow velocity of the portal and hepatic veins were increased after intravenously administration of the USCA, ranging from 10% to 13%. However, the changes were not statistically significant (P=0.097, 0.103, 0.128, and 0.190, respectively). There were no significant differences in other measured parameters, including the resistive index (P=0.205) and systolic acceleration time (P=0.489) of the hepatic artery and venous pulsatility index (P=0.494) of the hepatic vein.ConclusionsThe measured velocities of graft hepatic vessels tended to increase after administration of USCA, but without statistical significance. The comparison of serial Doppler parameters with or without injection of USCA is valid during Doppler surveillance in recipients of LT.

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Section: Discussionmentioning

confidence: 99%