Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast‐enhanced ultrasound: An animal study

Ying, Michael; Leung, Gina; Lau, Thomas Y.H.; Tipoe, George L.; Lee, Esther S.T.; Yuen, Q.W.H.; Huang, Y. P.; Zheng, Yongping

doi:10.1002/jcu.21969

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…Studies had shown that CEUS is an accurate method for distinguishing severe and benign liver fibrosis . The liver is an organ in which blood is supplied by both hepatic artery and portal vein.…”

Section: Discussionmentioning

confidence: 99%

“…Studies had shown that CEUS is an accurate method for distinguishing severe and benign liver fibrosis. 6,22 The liver is an organ in which blood is supplied by both hepatic artery and portal vein. At the stage of liver fibrosis, an extrahepatic shunt has not formed yet, and the characteristics of microcirculation changes are mainly intrahepatic shunt: First, there is formation of an abnormal connection between the portal vein and hepatic vein; then, there is a short-circuit artery-vein short shunt from the formation of the connection between the artery and vein because of the reconstruction of the hepatic lobule in liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

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Contrast‐enhanced ultrasound and computerized tomography perfusion imaging of a liver fibrosis–early cirrhosis in dogs

Liu

Zhang

et al. 2016

J of Gastro and Hepatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Contrast‐enhanced ultrasound and computerized tomography perfusion imaging of a liver fibrosis–early cirrhosis in dogs

Liu

Zhang

et al. 2016

J of Gastro and Hepatol

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“…The DPI, defined as the maximum echo decibel of the TIC, assesses the perfusion of organs. In animal model, Ying M et al showed that the measurement of the liver parenchymal DPI was helpful for the evaluation of liver fibrosis, and the DPI decreased with advancing stages of fibrosis [24]. Atri M et al found that the DPI increased significantly in malignant renal masses compared to benign with visible changes in vascularity [25].…”

Section: Discussionmentioning

confidence: 99%

Improving Prognostic and Fibrotic Evaluation of Chronic Kidney Disease with Contrast‐Enhanced Ultrasound Index Derived Peak Intensity: an observational study

Xu¹,

H²,

Wang³

et al. 2019

Preprint

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Background Chronic kidney disease (CKD) is a progressive disease with high morbidity and mortality. Contrast-enhanced ultrasonography (CEUS) has emerged as a cost-effective novel non-invasive imaging technique to improve the diagnosis and predict CKD progression. Methods Patients diagnosed with CKD who underwent CEUS with intravenous bolus contrast 1.5 ml SonoVue during 2014 to December 2014 at Ren Ji hospital, Shanghai, China, were enrolled in this study. Time-intensity curves and quantitative indexes were created using QLAB quantification software. Kidney biopsies were analyzed with α-SMA immunohistochemistry. The Cox proportional hazards model was used to investigate the risk factors for kidney survival. Results Out of 167 CKD patients followed for a median of 23.6±11.3 months, 29 (17.4%) exhibited CKD progression with decline in glomerular filtration rate of more than 25% or end-stage renal disease. Multivariate Cox regression analysis revealed lower derived peak intensity (DPI) was independently associated with progression of kidney disease. Patients with DPI≤11.98db had more severe renal fibrosis and less likely to recover from CKD progression. Conclusions This study demonstrated that the DPI is a reliable CEUS parameter for the evaluation of renal function and independent predictor for the prognosis of CKD patients.

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“…Briefly, we initially identified the spleens of the rats with grey-scale ultrasound, and on the basis of these findings, we firstly evaluated the splenic haemoperfusion with colour Doppler ultrasound. Then, we switched the sonographic unit to the contrast-tuned imaging mode, and an ultrasound contrast agent (SonoVue, Bracco International, Amsterdam, the Netherlands) at a dose of 0.1 ml/kg was administered as a bolus into the caudal vein of the rat, followed by a 0.15 ml saline flush [ 31 , 32 ]. Immediately after injection, continuous scanning of the spleen was conducted to evaluate further the splenic haemoperfusion.…”

Section: Methodsmentioning

confidence: 99%

The diffuse reduction in spleen density: an indicator of severe acute pancreatitis?

et al. 2017

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We observed that acute pancreatitis (AP) was associated with diffuse reduction in spleen density (DROSD) in some patients. Furthermore, the condition of these patients was more serious, and the potential relationship between DROSD and structural and functional injury of the spleen remained unclear. Therefore, we performed a preliminary exploration of these factors. We analysed pertinent clinical data for AP patients with normal spleen density (control group) and for those with DROSD (reduction group) at the First Affiliated Hospital of Harbin Medical University (June 2013–June 2015). We measured the immunoglobulin M (IgM) B-cells of the AP patients and examined pancreatic and splenic tissues from AP rats with optical microscopy and TEM. The reduction group had a higher acute physiology and chronic health evaluation II (APACHE II) score, a longer length of stay (LOS) and lower serum calcium than the control group. The levels of triglycerides (TG) and total cholesterol (TC) did not differ significantly between the two groups. The percentage of IgM memory B-cells was significantly lower in the DROSD group than in the control group. TEM revealed that the spleen T-lymphocytes were normal in AP rats, but pyroptotic and necrotic spleen B-cells were observed in the severe AP rats. In AP, DROSD was an independent indicator of more severe conditions. Furthermore, spleen B-lymphocytes showed obvious damage at the cellular level, and the immunological function of the spleen was down-regulated when AP was associated with DROSD.

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Evaluation of liver fibrosis by investigation of hepatic parenchymal perfusion using contrast‐enhanced ultrasound: An animal study

Abstract: This animal study showed that CEUS has the potential to be a complementary imaging tool in the evaluation of liver fibrosis.

Cited by 8 publications

References 21 publications

Contrast‐enhanced ultrasound and computerized tomography perfusion imaging of a liver fibrosis–early cirrhosis in dogs

Contrast‐enhanced ultrasound and computerized tomography perfusion imaging of a liver fibrosis–early cirrhosis in dogs

Improving Prognostic and Fibrotic Evaluation of Chronic Kidney Disease with Contrast‐Enhanced Ultrasound Index Derived Peak Intensity: an observational study

The diffuse reduction in spleen density: an indicator of severe acute pancreatitis?

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