Hepatic angiosarcoma: Aspiration biopsy cytology and immunocytochemical contribution

Saleh, Husain; Tao, Liang Che

doi:10.1002/(sici)1097-0339(199803)18:3<208::aid-dc9>3.0.co;2-9

Cited by 27 publications

(14 citation statements)

References 8 publications

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“…These nucleoli had a distinctive bar or bullet shape and were 5 or more times longer than they were wide. The nucleoli in angiosarcoma have been previously described as absent, small, or prominent in previous studies . Pencillate nucleoli have been described in histologic resections of angiosarcoma and are highly suggestive of angiosarcoma.…”

Section: Discussionmentioning

confidence: 80%

Cytologic features of angiosarcoma: A review of 26 cases diagnosed on FNA

Geller

HooKim

Sullivan

et al. 2016

Cancer Cytopathology

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BACKGROUND: This study describes the cytologic features of 26 angiosarcomas diagnosed on fine-needle aspiration.METHODS: Twenty-six angiosarcomas from 20 patients were confirmed by cytomorphology and immunocytochemical (immunohistochemistry) positivity for at least 2 of 3 vascular markers. Specimens were examined for spindled/epithelioid/plasmacytoid single cells, 3-dimensional clusters, multiple prominent/bar-shaped nucleoli (5 times longer than their width), chromatin strands, abnormal mitoses, necrosis, and vasoformative features. RESULTS: Eight males and 12 females with a mean age of 52 years (range, 2-94 years) underwent aspiration of tumors in the following: soft tissue or skin/subcutis (n 5 10), bone (n 5 4), nodes (n 5 5), lung (n 5 2), liver (n 5 2), heart (n 5 1), parotid gland (n 5 1), and pleural fluid (n 5 1). An angiosarcoma diagnosis was rendered for 24 of the 26 cases (92%); 1 was diagnosed as "atypical cells, cannot exclude angiosarcoma," and another was diagnosed as a malignant vascular neoplasm. Abnormal mitoses were most frequent (85%), and they were followed by single malignant cells (81%: epithelioid [69%], spindled [62%], and plasmacytoid[19%]), 3-dimensional clusters (54%), multiple prominent (62%) or bar-shaped nucleoli (54%), and chromatin strands (31%). Vasoformative features, including hemophagocytosis (54%), cytoplasmic lumina/vacuoles (69%) containing red blood cells (54%)/neutrophils (31%), and endothelial wrapping (69%), were seen in 88%; 23% had all vasoformative features, 88% had at least 1, and 12% had none. CONCLUSIONS: Angiosarcomas show a range of cytomorphologic features that make them potentially recognizable on cytology. Although vasoformative features are highly suggestive, they are not specific for angiosarcoma and may be seen in some nonvascular neoplasms. Immunohistochemistry and a high index of suspicion are required for an accurate diagnosis. Cancer Cytopathol 2016;124:659-68.

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Section: Discussionmentioning

confidence: 80%

Cytologic features of angiosarcoma: A review of 26 cases diagnosed on FNA

Geller

HooKim

Sullivan

et al. 2016

Cancer Cytopathology

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“…On immunohistochemical staining, the tumor cells were found to be positive for cluster of differentiation (CD)31 which originated from the vascular endothelium, supporting a diagnosis of hepatic angiosarcoma ( Fig. 4D) (9). Partial areas of the tumor showed necrosis during TAE.…”

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confidence: 65%

The Natural History of a Hepatic Angiosarcoma that was Difficult to Differentiate from Cavernous Hemangioma

et al. 2012

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A 69-year old man came to our hospital complaining of abdominal pain. Contrast-enhanced computed tomography (CT) showed a 65-mm ruptured mass in Couinaud segment 5 of the liver. The mass was treated with emergent transcatheter arterial embolization (TAE), followed by partial hepatectomy. Microscopically, the mass was determined to be an angiosarcoma. Six months previously, enhanced CT had shown a 15-mm mass diagnosed as a cavernous hemangioma in the same region of the liver. Even when the enhancement pattern of a small hepatic mass resembles that of hemangioma, the mass should be reassessed within several months to exclude a diagnosis of hepatic angiosarcoma.

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“…The diagnosis of HAS can be very difficult despite the introduction of nuclear magnetic imaging [23]. As liver needle biopsy does not many times allow making a correct diagnosis, adequate tissue sampling (using excision biopsy) is of utmost importance to avoid futile surgery.…”

Section: Hepatic Haemangiosarcomamentioning

confidence: 99%

Liver transplantation and vascular tumours

Bonaccorsi‐Riani¹,

Lerut²

2010

Transplant International

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Summary Based on analysis of the literature and of the audited ELITA (European Liver Intestinal Transplant Association)–ELTR (European Liver Transplant Registry) data, the place of liver transplantation (LT) in the treatment of vascular tumours is discussed. Hepatic epithelioid haemangioendothelioma has currently become a good indication for LT with 5‐ and 10‐year post‐LT patient survival rates of 83% and 74% respectively and 5‐ and 10‐year recurrence‐free survival rates of 82% and 64% respectively. In contrast, the results of LT for haemangiosarcoma (HAS) are disastrous with an universal tumour recurrence within 6 months and no single patient survival after 2 years. Therefore, HAS remains an absolute contraindication to LT. The value of LT in the treatment of infantile haemangioendothelioma is more difficult to evaluate because of the very reduced number of reported cases and because of the often difficult differential diagnosis with angiosarcoma. LT should be reserved to those children not responding to medical treatment on the condition that sarcomatous modifications are excluded by expert pathologists to avoid a futile transplant procedure.

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Hepatic angiosarcoma: Aspiration biopsy cytology and immunocytochemical contribution

Cited by 27 publications

References 8 publications

Cytologic features of angiosarcoma: A review of 26 cases diagnosed on FNA

Cytologic features of angiosarcoma: A review of 26 cases diagnosed on FNA

The Natural History of a Hepatic Angiosarcoma that was Difficult to Differentiate from Cavernous Hemangioma

Liver transplantation and vascular tumours

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