Hepatic and muscle expression of thyroid hormone receptors in association with body and muscle growth in large yellow croaker, Pseudosciaena crocea (Richardson)

Yang, Xia; Xie, Jingjing; Wu, Tingfeng; Yue, Gen Hua; Chen, Jie; Zhao, Ruqian

doi:10.1016/j.ygcen.2007.01.005

Cited by 38 publications

(16 citation statements)

References 46 publications

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“…THs exert their effects by binding to specific TRs in the HPT axis in fish and play major roles in embryogenesis and larval development (Marchand et al, 2001;Yang et al, 2007). In this experiment, the mRNA expression of two TR subtypes (TRa, TRb) was both significantly down-regulated.…”

Section: Discussionmentioning

confidence: 67%

Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

et al. 2012

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Section: Discussionmentioning

confidence: 67%

Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

et al. 2012

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“…The biological activities of THs are predominantly mediated at the level of gene transcription, by binding to TRs in the HPT axis in fish (Liu et al, 2000;Marchand et al, 2001;Yang et al, 2007). TRa and TRb were up-and down-regulated, respectively, indicating a different response of TR isoforms to PFOS exposure.…”

Section: Discussionmentioning

confidence: 99%

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

et al. 2009

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“…The biological activity of TH is predominantly mediated at the level of gene expression by binding to thyroid hormone receptors in fish (Liu et al, 2000;Marchand et al, 2001;Yang et al, 2007). Several environmental contaminants interfere with the regulatory network of TH by binding to the TR (Ulrich, 2003;Schriks et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery

Zha

Spear

et al. 2009

Aquatic Toxicology

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a b s t r a c tThyroid hormones (THs) play an important role in the development and metabolism of fish through their influences on genetic transcription and are targets for endocrine disruptive agents in the aquatic environment. Amitrole is a pesticide potentially interfering with thyroid hormone regulation. In this study, the rare minnow (Gobiocypris rarus) was exposed to different levels of 3-amino-1,2,4-triazole (amitrole) and allowed to recover in clean water. Plasma TH levels and the expression of TH-related genes, including transthyretin (ttr), deiodinases (d1 and d2), and the thyroid hormone receptor (tr˛) from the livers and brains were evaluated. After exposure, the plasma TH levels did not change. Histopathological observations showed that livers were degenerated at 10,000 ng/l and these damages could be recovered by the withdrawal of amitrole. However, the ttr, d1, and d2 mRNA levels in the livers of males were significantly up-regulated in all exposure groups (p < 0.05). The ttr and d2 mRNA levels were significantly up-regulated at 10,000 ng/l and 10, 100, and 1000 ng/l in the livers of females, respectively (p < 0.05). In the brains of males, a twofold increase of d2 mRNA levels at ≥100 ng/l and a fivefold decrease of tr˛mRNA levels at ≥10 ng/l were observed (p < 0.05), whereas no significant differences were observed in the expression of d2 and tr˛in the brains of females. After a recovery period, the ttr, d1, and d2 mRNA levels in the livers of males returned to control levels, but the tr˛mRNA levels were irreversibly decreased at all treatments (p < 0.05). In addition, the d2 mRNA levels in the livers of females were significantly induced at ≥100 ng/l. Moreover, the d2 mRNA levels in the brains of males and females were up-regulated at 10,000 ng/l. These results indicated that amitrole exposure could result in alternations of ttr, d1, d2, and tr˛gene expression in different tissues of the rare minnow. The expression of these TH-related genes in males was more sensitive to amitrole than those of females. Recovery in clean water was associated with the selective regulation of TH-related gene transcription in the rare minnow. Therefore, these TH-related genes can serve as biomarkers to screen the effects of thyroid disruption chemicals in rare minnow.

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Hepatic and muscle expression of thyroid hormone receptors in association with body and muscle growth in large yellow croaker, Pseudosciaena crocea (Richardson)

Cited by 38 publications

References 46 publications

Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

Waterborne exposure to microcystin-LR alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis in zebrafish larvae

Waterborne exposure to PFOS causes disruption of the hypothalamus–pituitary–thyroid axis in zebrafish larvae

Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery

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