Hepatic abscess caused bySalmonella typhi

Soni, Paresh N.; Hoosen, Anwar A.; Pillay, D.

doi:10.1007/bf02087778

Cited by 29 publications

(6 citation statements)

References 10 publications

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“…Although whether hyper-capsule S . Typhi was involved is unknown, typhoid fever cases with liver abscess, in some cases, with gallbladder colonization, have been reported 75–80 .…”

Section: Discussionmentioning

confidence: 99%

Single missense mutations in Vi capsule synthesis genes confer hypervirulence toSalmonellaTyphi

Lee,

Song

2024

Preprint

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Many bacterial pathogens, including the human exclusive pathogenSalmonellaTyphi, express capsular polysaccharides as a crucial virulence factor. Here, throughS.Typhi whole genome sequence analyses and functional studies, we found a list of single point mutations that makeS. Typhi hypervirulent. We discovered a single point mutation in the Vi biosynthesis enzymes that control the length or acetylation of Vi is enough to create different capsule variants ofS.Typhi. All variant strains are pathogenic, but the hyper-capsule variants are particularly hypervirulent, as demonstrated by the high morbidity and mortality rates observed in infected mice. The hypo-capsule variants have primarily been identified in Africa, whereas the hyper-capsule variants are distributed worldwide. Collectively, these studies increase awareness about the existence of different capsule variants ofS.Typhi, establish a solid foundation for numerous future studies onS.Typhi capsule variants, and offer valuable insights into strategies to combat capsulated bacteria.

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“…Although whether hyper-capsule S . Typhi was involved is unknown, typhoid fever cases with liver abscess, in some cases, with gallbladder colonization, have been reported 75–80 .…”

Section: Discussionmentioning

confidence: 99%

Single missense mutations in Vi capsule synthesis genes confer hypervirulence toSalmonellaTyphi

Lee,

Song

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Although whether hyper Vi capsule S . Typhi was involved is unknown, typhoid fever cases with liver abscess, in some cases, with gallbladder colonization, have been reported 75 – 80 .…”

Section: Discussionmentioning

confidence: 99%

“…In human infection sites, diarrhea and overall weakness are known general typhoid fever clinical signs. Although whether hyper Vi capsule S. Typhi was involved is unknown, typhoid fever cases with liver abscess, in some cases, with gallbladder colonization, have been reported [75][76][77][78][79][80] .…”

Section: Discussionmentioning

confidence: 99%

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

Lee,

Song

2024

Nat Commun

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Many bacterial pathogens, including the human exclusive pathogen Salmonella Typhi, express capsular polysaccharides as a crucial virulence factor. Here, through S. Typhi whole genome sequence analyses and functional studies, we found a list of single point mutations that make S. Typhi hypervirulent. We discovered a single point mutation in the Vi biosynthesis enzymes that control Vi polymerization or acetylation is enough to result in different capsule variants of S. Typhi. All variant strains are pathogenic, but the hyper Vi capsule variants are particularly hypervirulent, as demonstrated by the high morbidity and mortality rates observed in infected mice. The hypo Vi capsule variants have primarily been identified in Africa, whereas the hyper Vi capsule variants are distributed worldwide. Collectively, these studies increase awareness about the existence of different capsule variants of S. Typhi, establish a solid foundation for numerous future studies on S. Typhi capsule variants, and offer valuable insights into strategies to combat capsulated bacteria.

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“…[ 6 ] S. typhi can involve a hepatobiliary system and cases of S. typhi liver abscess have been reported in the literature. [ 1 2 ]…”

Section: Discussionmentioning

confidence: 99%

“…These extraintestinal infections can involve liver, spleen, lung, bones, joints, endocardium, or central nervous system. [ 1 2 3 4 5 6 7 8 9 ] Genitourinary infections by S. typhi are relatively rare. A renal abscess is commonly caused by Staphylococci , Escherichia coli , Klebsiella , and Proteus .…”

Section: Introductionmentioning

confidence: 99%

Renal Abscess Caused by Salmonella Typhi

et al. 2015

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Salmonella typhi is a true pathogen, which is capable of causing both intestinal and extraintestinal infections. Unusual presentations of Salmonella should always be kept in mind as this organism can cause disease in almost any organ of the body. S. typhi has been reported to cause the life-threatening infections such as meningitis, endocarditis, myocarditis, empyema, and hepatic abscess. Renal involvement by S. typhi is a relatively rare presentation. We report a case of renal abscess caused by S. typhi in an afebrile, 10-year-old child who did not have any clinical history of enteric fever. To our knowledge, this is the first reported case of isolation of S. typhi from the renal abscess, and interestingly this isolate was found to be resistant to quinolones.

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Hepatic abscess caused bySalmonella typhi

Cited by 29 publications

References 10 publications

Single missense mutations in Vi capsule synthesis genes confer hypervirulence toSalmonellaTyphi

Single missense mutations in Vi capsule synthesis genes confer hypervirulence toSalmonellaTyphi

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

Renal Abscess Caused by Salmonella Typhi

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