Hepatho-nephroprotective and antioxidant effect of stem bark of &amp;lt;i&amp;gt;Allanblackia gabonensis&amp;lt;/i&amp;gt; aqueous extract against acetaminophen-induced liver and kidney disorders in rats

Vouffo, Edwige Ymele Chiogo; Donfack, Flaure Metchi; Temdie, Romeo Joel Guemmogne; Ngueguim, Florence Tsofack; Donfack, Jean Hubert; Dzeufiet, Désirè Djomeni; Dongmo, Alain Bertrand; Dimo, Théophile

doi:10.5455/jeim.270812.or.042

Cited by 11 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, they contain many types of polyhydroxy phenol compounds, which can function as natural antioxidants in humans and animals [27, 28]. Accordingly, the present study was undertaken to assess the effect of VN in rat model of chronic liver disease in order to confirm that this plant does indeed have a preventive benefit in liver disease.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Role of Ethanolic Extract ofVitex negundoin Thioacetamide-Induced Liver Fibrosis in Male Rats

Kadir

Kassim

Abdulla

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The hepatoprotective activity of ethanolic extract from the leaves of Vitex negundo (VN) was conducted against thioacetamide- (TAA-) induced hepatic injury in Sprague Dawley rats. The therapeutic effect of the extract was investigated on adult male rats. Rats were divided into seven groups: control, TAA, Silymarin (SY), and VN high dose and low dose groups. Rats were administered with VN extract at two different doses, 100 mg/kg and 300 mg/kg body weight. After 12 weeks, the rats administered with VN showed a significantly lower liver to body weight ratio. Their abnormal levels of biochemical parameters and liver malondialdehyde were restored closer to the normal levels and were comparable to the levels in animals treated with the standard drug, SY. Gross necropsy and histopathological examination further confirmed the results. Progression of liver fibrosis induced by TAA in rats was intervened by VN extract administration, and these effects were similar to those administered with SY. This is the first report on hepatoprotective effect of VN against TAA-induced liver fibrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Role of Ethanolic Extract ofVitex negundoin Thioacetamide-Induced Liver Fibrosis in Male Rats

Kadir

Kassim

Abdulla

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The increase in the levels of these marker enzymes in serum indicates damage in the liver cells [ 34 ]. Serum total bilirubin is considered as one of the reliable tests to assess the liver function as well as reflecting the ability of the liver to take up and process bilirubin into bile [ 35 ]. High levels of total bilirubin in the APAP- treated rats may be due to drug toxicity.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and Antioxidant Effects ofLotus corniculatuson Paracetamol-induced Hepatitis in Rats

Baali

Mezrag

Bouheroum

et al. 2020

AIAAMC

View full text Add to dashboard Cite

Background: Herbal medicines have been used in the treatment of liver diseases for a long time. The current study was elaborated to evaluate in vitro and in vivo antioxidant and anti-inflammatory effects of Lotus corniculatus (L. corniculatus) butanolic extract. Methods: The in vitro antioxidant and anti-inflammatory properties of L. corniculatus were investigated by employing DPPH radical scavenging, H2O2 scavenging and BSA denaturation assays. In vivo antioxidant and anti-inflammatory effects of L. corniculatus were evaluated against paracetamol (APAP)-induced hepatitis in rats. L.corniculatus at doses of 100 and 200 mg/kg was administered orally once daily for seven days. Serum transaminases (AST and ALT) and lactate dehydrogenase (LDH), total bilirubin levels, liver malondialdehyde (MDA), reduced glutathione (GSH), glutathione S- transferase (GST) and superoxide dismutase (SOD) levels and inflammatory markers, such as serum Creactive protein (CRP), circulating and liver myeloperoxidase (MPO) levels were investigated. Further histopathological analysis of the liver sections was performed to support the effectiveness of L. corniculatus. Results: L. corniculatus exhibited strong antioxidant and anti-inflammatory effects in vitro. In the in vivo study, our findings demonstrate that L. corniculatus (100 and 200 mg/kg) administration led to an amelioration of APAP effects on liver histology, liver functions parameters (AST, ALT, LDH, and total bilirubin levels) and liver oxidative stress markers (MDA, GSH, GST and SOD levels). Furthermore, serum CRP, circulating MPO and liver MPO levels were declined by both doses of L. corniculatus extract. The best benefits were observed with 200 mg/kg of L. corniculatus extract. Conclusion: Antioxidant and anti-inflammatory effects of L. corniculatus extract may be due to the presence of active components.

show abstract

“…The aqueous suspension of the stem bark of A. gabonensis showed significant hepatho-nephroprotective activity against acetaminophen-induced liver and kidney disorders in rats. In this, study the pre-treatment with 100 and 200 mg/kg significantly reduced the serum level of MDA, increase in enzymatic antioxidant activities (SOD and CAT) and non enzymatic antioxidant (GSH) levels [111]. The stem bark of this plant has been known to elaborate the following compounds xanthones, benzophenone, flavonoide, and phytosterol [112].…”

Section: Allanblackia Gabonensismentioning

confidence: 91%

African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

View full text Add to dashboard Cite

Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

show abstract

Hepatho-nephroprotective and antioxidant effect of stem bark of <i>Allanblackia gabonensis</i> aqueous extract against acetaminophen-induced liver and kidney disorders in rats

Cited by 11 publications

References 46 publications

Hepatoprotective Role of Ethanolic Extract ofVitex negundoin Thioacetamide-Induced Liver Fibrosis in Male Rats

Hepatoprotective Role of Ethanolic Extract ofVitex negundoin Thioacetamide-Induced Liver Fibrosis in Male Rats

Anti-inflammatory and Antioxidant Effects ofLotus corniculatuson Paracetamol-induced Hepatitis in Rats

African natural products with potential antioxidants and hepatoprotectives properties: a review

Contact Info

Product

Resources

About