Hepatectomy for oligo-recurrence of non-small cell lung cancer in the liver

Abstract

Hepatectomy may be equally effective as multidisciplinary therapy for oligo-recurrence of NSCLC in the liver.

Pulmonary Oligometastases Treated by Stereotactic Body Radiation Therapy: A Nationwide Survey of 1,378 Patients

“…He et al reported that in cancer patients with lung oligometastases from NSCLC, the median survival time of patients treated by surgery was higher than that of patients treated by systemic chemotherapy (18.2 vs. 9.1 months, p<0.05), although only 21 patients were included in that study (9). In another study of 7 patients who underwent hepatic resection for oligo-recurrence of NSCLC in the liver, the median survival time was 24.0 months (range=15.2-30.2), and 4 patients remained alive at the end of follow-up (23.4-30.2 months) (10). Lodeweges et al reported that the 5-year OS of patients with pulmonary oligometastaes who underwent surgery for LC was similar to that of patients who underwent stereotactic ablative radiation therapy (SABR) (41% and 45%, respectively), suggesting SABR as a more effective and less invasive treatment method for pulmonary oligometastases; however, this was a small population-based retrospective study (11).…”

Survival after recurrence following surgical resected non-small cell lung cancer: A multicenter, prospective cohort study

“…Oligorecurrence is usually defined as 3 to 5 or less distant metachronous metastases that can be treated with local therapy with controlled primary lesions. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Although the role of radical treatment for oligorecurrence is not well established, the subgroup of patients who received radical therapy, such as surgery or definitive radiotherapy, showed good PRS. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Indeed, a multivariate analysis showed that patients with oligorecurrence had a better PRS than those with multiple recurrences in this study.…”

“… 2 , 3 , 4 , 5 Indeed, thoracic oligorecurrence of NSCLC has been reported to show a favorable outcome in a select population. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 Although there is currently no clear consensus concerning the most appropriate treatment, local therapy, such as surgery, radiotherapy, or chemoradiotherapy, might be a common treatment option. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 In addition, some patients who receive appropriate treatment might obtain a cure for recurrent disease.…”

Hepatectomy for rapidly growing solitary liver metastasis from non-small cell lung cancer: a case report

“…Here, we performed a right hepatectomy for a rapidly growing giant liver metastasis from NSCLC, and the patient did not present recurrence 41 months after the hepatectomy and 54 months after the lung resection. Although the liver is not a common recurrence site [3], and reported cases of hepatectomies for liver metastases from NSCLC are rare [4], we recommended surgical resection to this patient. Since the tumor showed substantial growth after we overlooked the liver lesion 6 months before the initial recognition and the new metastatic lesion did not emerge during the 6-month interval, we considered that the liver metastasis could be an oligo-metastasis.…”

“…Since the liver is rarely observed as an oligo-recurrence/metastasis site in patients with NSCLC [1], hepatectomies for liver metastasis from NSCLC have rarely been reported [4]. We encountered a patient with a rapidly growing solitary liver mass lesion that developed after lung resection for NSCLC and treated the patient using a hepatectomy.…”