Heparin Resistance in Acute Coronary Occlusion Measured by the Plasma Heparin Thrombin Time

Holger-Madsen, T

doi:10.1159/000206241

Cited by 20 publications

(6 citation statements)

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“…Increased heparin tolerance is regularly seen during the acute stage of inflammatory and degenerative diseases, i.e., conditions associated with increased frequency of thrombo embolic complications [7,10,11].…”

Section: Introductionmentioning

confidence: 99%

The Antiheparin Effect of α<sub>1</sub>-Acid Glycoprotein and Platelet Material, Evaluated by the Heparin Thrombin Clotting Time

Andersen¹,

Godal²

1977

Pathophysiol Haemos Thromb

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The effect on the heparin thrombin clotting time (HTCT) of a so-called acute phase protein, α₁-acid glycoprotein, was studied in test systems consisting of purified fibrinogen, antithrombin III, heparin and thrombin, and compared to the effect of platelet material (crude platelet factor 4). In these test systems a physiological concentration of α₁-acid glycoprotein (1 g/l) inhibited heparin more effectively than did soluble platelet material from 200 × 10⁹ platelets/1. The present observations suggest that α₁-acid glycoprotein is of great significance for the so-called heparin tolerance, whereas platelet material proved less important.

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Section: Introductionmentioning

confidence: 99%

The Antiheparin Effect of α<sub>1</sub>-Acid Glycoprotein and Platelet Material, Evaluated by the Heparin Thrombin Clotting Time

Andersen¹,

Godal²

1977

Pathophysiol Haemos Thromb

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“…When assayed by various clotting methods, the clotting times recorded at a given heparin concentration (i.e., anticoagulant effect of heparin in the clotting systems used) are fairly similar in blood or plasma from healthy individuals [11,12,22], but may vary considerably in blood or plasma from patients, especially in 'acute phase' situations [11,12,22]. These clotting time variations are often said to reflect the so-called heparin tolerance which again may be considered as the net effect of factors influencing the anti coagulant effect of heparin in vitro, and most likely also in vivo [10].…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies on heparin tolerance, whole plasma was used as substrate [9,[11][12][13]. As a consequence, the effect of separate factors could not be satisfactorily evaluated.…”

Section: Introductionmentioning

confidence: 99%

The Anticoagulant Effect of Heparin + Antithrombin III Using Purified Fibrinogen as Substrate

Andersen¹,

Godal²

1977

Pathophysiol Haemos Thromb

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The anticoagulant effect of heparin in test systems composed of purified factors [antithrombin III (AT-III), fibrinogen and thrombin] was studied. As expected, the sensitivity to heparin depended on the concentrations of AT-III and thrombin, whereas the fibrinogen level was less decisive. In addition, qualitative differences proved important. Thus, the sensitivity to heparin was greater with crude bovine thrombin than with highly purified thrombin from the same species. Further, the sensitivity to heparin increased following removal of cold-insoluble material from the fibrinogen preparation. Finally, during storage of purified AT-III at + 4 °C for more than 4 weeks, the sensitivity to heparin decreased more rapidly than expected from the amidolytic AT-III assays. Smaller amounts of heparm were required to give a prolonged thrombin clotting time than in whole plasma, indicating that components of normal platelet-poor plasma (besides AT-III and fibrinogen) interfere with the anticoagulant effect of heparin. The present test systems may prove suitable for the detection and evaluation of factors of importance for the so-called heparin tolerance.

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“…Thus an increase in antiheparin activity occurs in the week or two after surgery (Godal and Fichera, 1961;Holger-Madsen and Schi0ler, 1959;Gormsen and Haxholdt, 1960), after myocardial infarction (Beaumont, Chevalier, and Lenegre, 1948;Holger-Madsen, 1960), and after trauma (Innes and Sevitt, 1964). The mechanism underlying this phenomenon is not known but it is generally accepted to reflect increased coagulability.…”

mentioning

confidence: 99%

Plasma antiheparin activity and the heparin precipitable fraction of plasma in rheumatoid arthritis.

Cotton¹,

Johnson²

1968

Annals of the Rheumatic Diseases

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Heparin Resistance in Acute Coronary Occlusion Measured by the Plasma Heparin Thrombin Time

Cited by 20 publications

References 0 publications

The Antiheparin Effect of α<sub>1</sub>-Acid Glycoprotein and Platelet Material, Evaluated by the Heparin Thrombin Clotting Time

The Antiheparin Effect of α<sub>1</sub>-Acid Glycoprotein and Platelet Material, Evaluated by the Heparin Thrombin Clotting Time

The Anticoagulant Effect of Heparin + Antithrombin III Using Purified Fibrinogen as Substrate

Plasma antiheparin activity and the heparin precipitable fraction of plasma in rheumatoid arthritis.

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