Plasma antiheparin activity and the heparin precipitable fraction of plasma in rheumatoid arthritis.

Cotton, R.C.; Johnson, F. M.

doi:10.1136/ard.27.5.425

Cited by 7 publications

(1 citation statement)

References 20 publications

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“…Patients with rheumatoid arthritis have been reported to show antiheparin activity in blood plasma 37 and low levels of basophils. 38,39 Migraine can be the presenting symptom in systemic lupus erythematosus (SLE) 40 and some SLE patients have shown increased resistance to the lipolytic and anti-coagulant actions of heparin.…”

Section: Discussionmentioning

confidence: 99%

Prophylaxis of Migraine with Anionic Polyelectrolytes

Thonnard-Neumann

Bigelow

1988

Headache

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SYNOPSIS In previous studies on patients with migraine headaches we found that 50% had reduced concentrations of basophils and lymphocytes. Treatment with inhalations of heparin often restored these blood indices to normal and was accompanied by a reduction in migraine headache, We report here data on the long term treatment of 37 migraine patients with inhalations of heparin and with an oral semi‐synthetic heparinoid, Pentosan Polysulfate (PNP). 27 patients responded with a mean improvement in migraine index of 79% and as a group showed significant increases in basophil, total lymphocyte, and in particular T‐cell concentrations. Ten patients whose migraine headaches were related to their menstrual cycles were relatively unresponsive to heparin or PNP. They had a general leukopenia, but basophils were within normal range.

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Section: Discussionmentioning

confidence: 99%