Heparin-Network-Mediated Long-lasting Coatings on Intravascular Catheters for Adaptive Antithrombosis and Antibacterial Infection

Abstract

Bacteria-associated infections and thrombosis have become life-threatening complications to human health, particular in catheter-related bloodstream infections (CRBIs) and catheter-related thrombosis (CRT). Herein, multifunctional coating complex was fabricated by a concise assembly of heparin (HS) with organosilicon quaternary ammonium surfactants (DAC). Different from the conventional one-time coatings, obtained HS/DAC complex can attach on kinds of devices with arbitrary shapes and compositions via facile dip, and further form robust coatings for treating CRBIs and CRT simultaneously. Taking advantage of adaptive dissociation and robustness, HS/DAC coatings not only exhibit good stability even under extreme conditions, but also significantly reduce thrombus adhesion by 84.6% and broad-spectrum antibacterial activity (> 99%) in vitro and in vivo. Meanwhile, ex-vivo rabbit model was used to verify the good antibacterial infection and antithrombic performances of HS/DAC coated catheters during the implantation. Such a substrate-independent and portable long-lasting multifunctional coating meets the growing anti-CRBIs and CRT demands in clinic.