Heparin‐Like Macromolecules for the Modification of Anticoagulant Biomaterials

Ran, Fen; Nie, Shengqiang; Li, Jie; Su, Baihai; Sun, Shudong; Zhao, Changsheng

doi:10.1002/mabi.201100249

Cited by 87 publications

(82 citation statements)

References 37 publications

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“…[321,322] MMA [323] MMA [324] AA [325] DMAm [326] (DMAm) [326] NIPAm [321] AA/St [327] NIPAm/ 361 [328] NIPAm/362 [328] MAA/ CHAm/NIPAm [328] MAA/BzAm/ NIPAm [328] MAA/OAm/ NIPAm [328] MAA/NIPAm/361 [328] AA/St-b-NVP [327] MAA/NIPAm/ 362 [328] MMA-b-(PEGMA/ NIPAm) [323] (NVP-b-MMA) [329,330] O I/M [285] St [285] BA [285] 81…”

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confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(¼S)SR) by a mechanism of reversible addition-fragmentation chain transfer ( Chem. 2009Chem. , 62, 1402. This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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“…In this sense, material-surface modification by introducing heparin-like structures has been suggested to obtain antithrombogenic materials (Tamada et al 1998;Ran et al 2012). The introduction of sulfonated moieties in polysaccharides has been proposed as an alternative to heparin (Maas et al 2012) since it is believed that the activity of heparin is due to the presence of sulfate, sulfamide and carboxylic acid groups (Silver et al 1992;Tamada et al 1998Tamada et al , 2002.…”

Section: Introductionmentioning

confidence: 99%

Sulfonated nanocellulose beads as potential immunosorbents

et al. 2018

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Herein 2,3-dialdehyde cellulose beads prepared from Cladophora green algae nanocellulose were sulfonated and characterized by FTIR, conductometric titration, elemental analysis, SEM, f-potential, nitrogen adsorption-desorption and laser diffraction, aiming for its application as a potential immunosorbent material. Porous beads were prepared at mild reaction conditions in water and were chemically modified by sulfonation and reduction. The obtained 15 lm sized sulfonated beads were found to be highly charged and to have a high surface area of * 100 m 2 g -1 and pore sizes between 20 and 60 nm, adequate for usage as immunosorbents. After reduction of remaining aldehyde groups, the beads could be classified as non-cytotoxic in indirect toxicity studies with human dermal fibroblasts as a first screening of their biocompatibility. The observed properties make the sulfonated cellulose beads interesting for further development as matrix material in immunosorbent devices.

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“…[1][2][3][4] Polyethersulfone (PES) is one important polymeric material with high mechanical intensities, thermal stabilities, and chemical resistances. PES and PES-based membranes are widely used in the field of blood purification, owing to their good blood compatibility, and also in tissue engineering and artificial organs because of their good hemocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block -poly (acrylate-graft -poly(methyl methacrylate))-block -poly-(vinyl pyrrolidone)

Ran

Song

et al. 2015

Polym. Adv. Technol.

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Polyethersulfone (PES) membrane, one of the most important polymeric materials because of its good chemical resistance, thermal stability, mechanical, and film-forming properties, has already been used in hemodialysis, tissue engineering, and artificial organs. In order to improve the blood compatibility of PES membrane, many amphiphilic block copolymers have been synthesized and used as additives for surface modification. The object of this study is to develop a hydrophilic PES membrane by blending a comblike amphiphilic block copolymer poly (vinyl pyrrolidone)-block-poly [acrylate-graft-poly (methyl methacrylate)]-block-poly-(vinyl pyrrolidone) [PVP-b-P (AE-g-PMMA)-b-PVP] synthesized by RAFT polymerization. The cytocompatibility performance of PVP-b-P (AE-g-PMMA)-b-PVP modified PES membrane was evaluated, which showed better cytocompatibility compared with that of pristine PES membrane. Endothelial cells cultured on the modified membranes present improved growth in terms of scanning electron microscope observation, MTT assay, and confocal laser scanning microscope observation. These results indicate that the modified membrane has great potential application in blood-contact fields such as hemodialysis and bio-artificial liver supports.

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Heparin‐Like Macromolecules for the Modification of Anticoagulant Biomaterials

Cited by 87 publications

References 37 publications

Living Radical Polymerization by the RAFT Process – A Third Update

Living Radical Polymerization by the RAFT Process – A Third Update

Sulfonated nanocellulose beads as potential immunosorbents

Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block -poly (acrylate-graft -poly(methyl methacrylate))-block -poly-(vinyl pyrrolidone)

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