Heparin-like anticoagulant activity of sulphonated poly(ethylene oxide) and sulphonated poly(ethylene oxide)-grafted polyurethane

Han, Dong Keun; Lee, Nam Young; Парк, Ки Донг; Kim, Young Ha; Cho, Han Ik; Min, Byoung Goo

doi:10.1016/0142-9612(95)98819-z

Cited by 81 publications

(39 citation statements)

References 18 publications

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“…[4][5][6] In addition, PEO-SO 3 exhibited a heparin-like anticoagulant activity. 7 These results were explained by a synergistic effect of nonadhesive PEO chain motion and anticoagulant sulfonate group. The in vivo calcification resistance was increased in the order of PU Ͻ PU-PEO Ͻ PU-PEO-SO 3 , the same as the biostability and thromboresistance.…”

Section: Mechanism Of Calcification Resistance Of Peo-so 3 and Heparinmentioning

confidence: 94%

Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation

Lee

Парк

Kim

et al. 2001

J. Biomed. Mater. Res.

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A novel chemical modification of biological tissues was developed aimed at improving biocompatibility and calcification resistance. This method involved the additional grafting of sulfonated PEO (PEO-SO(3)) or heparin after conventional glutaraldehyde (GA) fixation of bovine pericardium (BP). The amino groups of PEO-SO(3) or heparin were utilized to react to the GA residues to block them. The PEO-SO(3) or heparin grafted tissues demonstrated a slightly higher shrinkage temperature and tensile strength, but greater resistance to collagenase digestion, than GA treated ones. These results suggest that modified tissues have improved durability due to the grafting and filling effect of PEO-SO(3) or heparin in addition to the GA cross-linking. At the direct contact cytotoxicity test in vitro, PEO-SO(3) or heparin grafted tissue was shown to be nontoxic, while relatively significant cytotoxicity was observed for the GA treated tissues, possibly due to the release of GA. From the in vivo calcification study, calcium contents deposited on the modified tissues were much less than those on GA treated tissues. Such a decreased calcification might be explained by the decrease of residual GA groups during the additional treatment, and the space-filling effect and the nonadhesive property and/or the blood compatibility of PEO-SO(3) or heparin grafted covalently. The newly modified tissue patch was observed to show improved pathological assessibility including less inflammation and tissue reactions. This simple modification method may be useful for calcification-resistant and blood-compatible tissue patches for cardiovascular implants.

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Section: Mechanism Of Calcification Resistance Of Peo-so 3 and Heparinmentioning

confidence: 94%

Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation

Lee

Парк

Kim

et al. 2001

J. Biomed. Mater. Res.

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“…In addition, after blending with SPES, the amount of FBG adsorption was further suppressed. The results indicated that the FBG adsorption was suppressed due to the synergistic effect of the ACOOH and the ASO 3 H groups, and the modified membrane surfaces might show a heparin-like anticoagulant activity [16].…”

Section: Protein Adsorptionmentioning

confidence: 99%

“…Thus, many studies have focused on the sulfonation of polymers. Sulfonated poly (ethylene oxide)-grafted PUs (PU-PEO-SO 3 ) showed an improved blood compatibility due to the heparin-like anticoagulant activities [16]. In addition, sulfonated poly (ethylene glycol) (PEG) containing methacrylate (MA) copolymers [15] or acrylate copolymers [17] also exhibited good blood compatibility.…”

Section: Introductionmentioning

confidence: 98%

Heparin-like surface modification of polyethersulfone membrane and its biocompatibility

Tang

Xue

Yan

et al. 2012

Journal of Colloid and Interface Science

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“…[20][21][22] Some researchers have attributed this better hemocompatibility to the heparin-like chemical structure, which contains sulfate ionic functionalities along the polymer backbone. 23,24 However, other factors such as microphase separation and chain mobility associated with the sulfonated polyurethane have been suggested to enhance the material's blood compatibility.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, surface characterization, and platelet reactivity evaluation for the self-assembled monolayer of alkanethiol with sulfonic acid functionality

Lin

Chuang

2000

J. Biomed. Mater. Res.

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Owing to the capability of fabricating a well-defined chemical structure on the surface, self-assembled alkanethiols with a variety of terminal functionalities were prepared on the gold substrate for investigating the interactions between the biological environment and synthetic surface. In this study, we report the synthesis of the sulfonic acid terminated long-chain alkanethiol, 10-mercaptodecane-sulfonic acid, for direct preparation of a self-assembled monolayer (SAM) with -SO(3)H functionality. Nuclear magnetic resonance (NMR) and elemental analysis studies indicated that a high purity of sulfonic acid terminated alkanethiol was obtained. Surface characterization results showed that the -SO(3)H terminated SAM is hydrophilic and has a slightly higher hysteresis value, possibly because of the slower chain mobility of the bound sulfonic acid alkanethiol. Electron spectroscopy for chemical analysis (ESCA) analysis demonstrated that the -SO(3)H terminal group is situated in the outermost layer of the monolayer, as previous alkanethiol SAM structure models proposed. The platelet reactivity of the -SO(3)H SAM was higher than that of -OH SAM but less than the -CH(3) terminated one in vitro, whereas similar platelet reactivity was noticed between the -SO(3)H and -COOH SAMs. The higher platelet reactivity found on the -SO(3)H SAM could be caused by the higher surface functional group density inherent in the SAM structure and/or the composition and conformation state of the adsorbed protein layer.

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Heparin-like anticoagulant activity of sulphonated poly(ethylene oxide) and sulphonated poly(ethylene oxide)-grafted polyurethane

Cited by 81 publications

References 18 publications

Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation

Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation

Heparin-like surface modification of polyethersulfone membrane and its biocompatibility

Synthesis, surface characterization, and platelet reactivity evaluation for the self-assembled monolayer of alkanethiol with sulfonic acid functionality

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