Heparin effect on blood viscosity

Abstract

~um~ary: ~he effect of heparin on blood viscosity was ~nvestl~ated In a group of patients with acute myocardial mfarctlon (AMI) and preinfarction angina (PA), whose blood viscosity was elevated. Viscosity was measured with Cannon, Fenske, and Routine viscometers. Kinematic viscosity, bath and whole blood, plasma, and serum viscosity were determined as well as dependent parameters (fibrinogen, serum proteins, number of platelets, and hematocrit). All of them were found to increase, and it was significantly proved that intravenous heparin immediately decreased plasma viscosity, but has a lesser effect on serum and whole blood viscosity. A dose of 1 cc = 50 mg = 5000 IU intravenous heparin, will maintain this decrease for' a month. In our four-week study, I cc Lv. heparin was administered at 6-hour intervals for the first 2 weeks, and 2 cc heparin subcutaneous injections were administered at 12-hour intervals for the next 2 weeks. We found that heparin also decreased fibrinogen, hematocrit, serum alpha2 globulin, and number of platelets. Hyperviscosity, hypercoagulability, and the mcrease of platelet' adhesiveness are some of the most important physiopathological alterations of AMI and PA. The decrease of blood viscosity due to heparin is one of the most important and beneficial effects of it in this pathology.

Heparin effect on plasma fibrinogen in the thrombophilic syndrome

“…Heparin however does normalize the thrombocytosis (Ruggiero et al, in press) and reduces the hyperviscosity of the blood (Ruggiero et al, 1982). This is to say that heparin acts on all the factors which we have described in the acute thrombophilic syndrome, including on the increased platelet adhesiveness (Ruggiero, et al, 1969;1972).…”

“…We have found that heparin reduces the plasma viscosity and to a lesser degree the whole blood and serum viscosity (Ruggiero et al, 1982). Heparin diminishes the blood hypercoagulability (Ruggiero and Fustinoni, 1964).…”

The acute effect of sublingual nifedipine and isosorbide dinitrate on plasma viscosity in patients with acute myocardial infarction

“…As in AMI, the perfhion pressure is low, hence the potential importance of blood viscosity. Ruggiero et al (1982) commenting upon hyperviscosity, suggest that this rheological disturbance is one of the most important pathophysiological alterations in AM1 and preinfarction angina. Gustafsson et a/.…”

“…Most workers (Bondoli et al, 1977;Dodds et al, 1980;Fuchs et ul., 1984;Harkness et ul., 1971Harkness et ul., , 1977Jan et al, 1975;Kellog et ul., 1960;Lowe et al, 1980;Ruggiero et al, 1982) reported a rise in P1.V in patients with active ischemic heart disease. Therefore, therapy aimed at lowering P1.V in ischemic heart disease may possibly have a beneficial effect in improving coronary blood flow in this condition.…”

Disappearance of Microembolic Signals after Heparin in Acute Cerebral Ischemia due to Cyanotic Heart Disease with Polyglobulia

“…Moreover, administration of heparin is known to cause a reduction of viscosity and also of markers of thrombus formation [31] . In our patient, who was already treated with aspirin, immediately after the infusion of heparin, there was a progressive reduction in the rate of embolization, ending with no recordable MES.…”