Henoch-Schönlein Purpura Triggered by Acute Hepatitis E Virus Infection

Thapa, Rajoo; Biswas, Biswajit; Mallick, Debkrishna

doi:10.1016/j.jemermed.2008.10.004

Cited by 30 publications

(15 citation statements)

References 6 publications

(4 reference statements)

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“…Thrombocytopenia has been reported in endemic and non‐endemic countries, and it is associated with immune mechanism . Hemolysis and other immunological manifestations have also been described such as membranoproliferative and membranous glomerulonephritis and Henoch–Schonlein purpura . Several neurological complications have been reported in the past years.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Hepatitis E: current status

Pérez‐Gracia

Lindemann

Villalba

2013

Reviews in Medical Virology

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Acute hepatitis E is a very common disease in developing countries, to the point that, according to World Health Organization estimates, one third of the world's population has been exposed to HEV. It also causes outbreaks in refugee camps or after natural disasters such as floods or earthquakes. Sporadic cases of acute hepatitis have been observed in practically all European countries and other developed geographical areas, not only in travelers from endemic countries but also in people with no risk factors. But, lately, new aspects of this infection are appearing in industrialized countries such as the possibility of the disease becoming chronic in transplant patients, the immunocompromised in general, and even in patients with previous liver disease who are immunocompetent. In this comprehensive review, we summarize the current knowledge on HEV infection.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Hepatitis E: current status

Pérez‐Gracia

Lindemann

Villalba

2013

Reviews in Medical Virology

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“…These include autoimmune thyroiditis, subacute thyroiditis and Grave's thyrotoxicosis. [86][87][88] In addition, a case of Henoch-Schönlein purpura triggered by acute HEV infection 89 and another case of HEV-induced myasthenia Gravis have been described. 90 Lastly, HEV infection may cause acute polyarthritis.…”

Section: Other Manifestationsmentioning

confidence: 99%

Extrahepatic manifestations of hepatitis E virus: An overview

2020

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Hepatitis E virus (HEV) is a significant health problem with approximately 20 million individuals infected annually. HEV infection has been associated with a wide spectrum of extrahepatic manifestations, including neurological, hematological and renal disorders. Guillain-Barré syndrome and neuralgic amyotrophy are the most frequent neurological manifestations. In addition, HEV infection has been observed with other neurological diseases, such as encephalitis, myelitis and Bell's palsy. Hematologic manifestations include anemia due to glucose-6-phospate dehydrogonase deficiency, autoimmune hemolytic anemia and severe thrombocytopenia. Membranoproliferative glomerulonephritis and relapse IgA nephropathy with or without coexisting cryoglobulinemia appear to be the most common renal injuries related with HEV infection. Also, HEV infection has been associated with acute pancreatitis and other immune-mediated manifestations, such as arthritis and myocarditis. However, the pathophysiologic mechanisms of HEV-related extrahepatic manifestations are still largely unclear.

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“…The literature included also 17 Henoch-Schönlein cases associated with an acute or chronic viral liver disease (39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52) and 4 preceded (53-56) by a hepatitis vaccination (Table 2).…”

Section: Henoch-schönlein Purpura Associated With a Viral Liver Diseamentioning

confidence: 99%

“…Flowchart of the literature search process. Ã Cases associated with infectious mononucleosis (N ¼ 1), primary biliary cirrhosis (N ¼ 1), or alcohol abuse (N ¼ 2); same case reported in >1 article (N ¼ 2); poorly described patients (N ¼ 1).Schönlein cases associated with pancreato-biliary involvement (7-38), 17 patients associated with a viral liver disease(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52) and 4 preceded (53-56) by a hepatitis vaccination. Using the aforementioned inclusion criteria, we always confirmed the diagnosis of Henoch-Schönlein purpura, pancreatitis, or cholecystitis established in the original publications.…”

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confidence: 99%