Hen Egg White Lysozyme Catalyzed Efficient Synthesis of 3-Indolyl-3-hydroxy Oxindole in Aqueous Ethanol

Enzymatic Synthesis of 3‐Hydroxy Bisindoles and Further C‐3 Sulfenylation via Combining a Carbocatalytic Approach in the Same Pot

“…Notably, the Chaudhari group presented a method in 2018, that employed hen egg white lysozyme (HEWL) as a catalyst to yield 3-hydroxy bisindoles (Scheme 1a). [18] Similarly, Sarvari and colleagues demonstrated the efficacy of blue light-emitting diodes (LEDs) as a catalyst for synthesizing substituted 3-hydroxy bisindoles (Scheme 1b). [19] Additionally, Kashinath et al reported the use of CuWO 4 nanoparticles at high temperatures to synthesize 3-hydroxy bisindoles (Scheme 1c).…”

“…Still, there are limited sustainable approaches available for synthesizing 3‐hydroxy bisindoles. Notably, the Chaudhari group presented a method in 2018, that employed hen egg white lysozyme (HEWL) as a catalyst to yield 3‐hydroxy bisindoles (Scheme 1a) [18] . Similarly, Sarvari and colleagues demonstrated the efficacy of blue light‐emitting diodes (LEDs) as a catalyst for synthesizing substituted 3‐hydroxy bisindoles (Scheme 1b) [19] .…”

Lipase‐mediated multicomponent synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐dione derivatives in a binary solvent medium

“…50 In continuation of the interest in biocatalysis and biotechnology, recently, we reported the use of enzymes as a biocatalyst to the synthesis of important bioactive heterocyclic compounds. 51,52 The lipase-catalyzed Knoevenagel condensation of benzaldehyde, and malononitrile/ethyl cyanoacetate is reported in an ethanol-water solvent system. 53 Here; we report an environmentally safe protocol comprising aldehydes, malononitrile, and phthalhydrazide for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives catalyzed by enzyme lipase from A. niger using water as a cosolvent.…”

“…Recently, this lipase is reported for the synthesis of butyl butyrate 50 . In continuation of the interest in biocatalysis and biotechnology, recently, we reported the use of enzymes as a biocatalyst to the synthesis of important bioactive heterocyclic compounds 51,52 . The lipase‐catalyzed Knoevenagel condensation of benzaldehyde, and malononitrile/ethyl cyanoacetate is reported in an ethanol–water solvent system 53 .…”