Hemostatic performance and biocompatibility of chitosan-based agents in experimental parenchymal bleeding

Surface configuration of microarc oxidized Ti with regionally loaded chitosan hydrogel containing ciprofloxacin for improving biological performance

“…Hence, it is clear that the relative low OD value and live cell number on the RLCH is attributed to the degradation of the hydrogel, but not the toxicity. In addition, chitosan hydrogel has been reported as a biocompatible material due to the biological specific interaction between its functional groups and the cell membrane receptor [ 41 ]. Therefore, regional loading of chitosan hydrogel on the surface hydrothermally treated MAO coating can impart both good biocompatibility and bioactivity to the Ti implants.…”

Functional electrospun nanofibers: fabrication, properties, and applications in wound-healing process

“…120 For example, combining the adhesive properties of electrostatically spun nanobers not only seals the wound to provide hemostasis 121 but also seamlessly adheres to the wound site for a long period, avoiding the potential risk of infection caused by contact between the wound and the external environment. 122,123 Jiang et al 124 rst used different concentrations of sodium hypochlorite (NaClO) to isolate SF to obtain multiscale silk bers (MSFs). These MSFs are then implanted into the PLA ber membrane by electrospinning to improve hydrophilicity.…”

“…120 For example, combining the adhesive properties of electrostatically spun nanofibers not only seals the wound to provide hemostasis 121 but also seamlessly adheres to the wound site for a long period, avoiding the potential risk of infection caused by contact between the wound and the external environment. 122,123…”

Strongly Adhesive, Self-Healing, Hemostatic Hydrogel for the Repair of Traumatic Brain Injury

“…A new approach to intracranial hemorrhage and brain injury repair is emerging through developments in materials science. , Various biomaterials, including gelatin, collagen, silk, alginate, hyaluronic acid, peptides, and polymers, , have been investigated for their potential in brain injury repair and rehabilitation. However, none of these materials are suitable for TBI and small cerebral artery hemostasis and sealing due to their poor hemostatic performance, high swelling rate, inadequate wet tissue surface adhesion, and weak or inflexible bonding mechanisms. − Hemostasis and sealing of the TBI and its cerebral arterial branches require rapid adhesion under continuous blood flow, low swelling rates, high mechanical strength to maintain blood pressure, and good tissue regeneration with excellent biocompatibility . However, it is extremely difficult to combine wet surfaces with dynamically organized surfaces at low swelling rates.…”