Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots

Yan, Xin; Zhao, Yan; Luo, Jian; Xiong, Wei; Liu, Xiaoman; Cheng, Jinjun; Wang, Yongzhi; Zhang, Meiling; Qu, Huihua

doi:10.1186/s12951-017-0296-z

Cited by 75 publications

(74 citation statements)

References 24 publications

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“…A range of applications has been developed for emerging nanomaterials including drug delivery [26], biological imaging [27], and optical catalysts [28]. NPs have been reported in other TCMs carbonised at high temperature including Pollen Typhae Carbonisata, Cirsium Setosum Carbonisata, Schizonepetae Herba Carbonisata, and Junci Medulla Carbonisata [5,[29][30][31]. The STC-NPs possessed components similar to those of other widely-studied nanoparticles [32,33].…”

Section: Molecules 2019 24 X For Peer Review 7 Of 13mentioning

confidence: 99%

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

et al. 2020

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High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4–2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy.

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Section: Molecules 2019 24 X For Peer Review 7 Of 13mentioning

confidence: 99%

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

et al. 2020

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“…To determine whether CSC-CDs are the hemostatic substance in CSC, the mouse tail amputation and liver scratch models were used according to previously published methods. [13][14][15] In brief, Kunming mice were divided into the following groups and subcutaneously injected as indicated: negative control (normal saline, NS); positive control (HC, 0.67 kU kg À1 ); and high-, medium-, and low-dose CSC-CDs (8.33, 3.33, and 1.67 mg kg À1 , respectively). The mouse were anesthetized with 4% pentobarbital sodium via intraperitoneal injection (50.0 mg kg À1 ).…”

Section: Hemostasis Studies Of Csc-cdsmentioning

confidence: 99%

Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata

et al. 2018

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“…However, most of these methods were less environmentally friendly and the processes were tedious. In this research, we developed a novel SSC-CDs with an average diameter of 1.29-6.87 nm and a quantum yield (QY) 6.31% and SSC were prepared by simply burning SS at 350 C for 1 h, according to a modified pyrolysis method [27][28][29]. As a charcoal drug, SSC naturally contained carbon, nitrogen and oxygen, which were necessary for the preparation route of SSC-CDs and might serve both as the carbon source and the passivation agent for CDs.…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, researches on self-bioactivity of CDs are on the rise [25][26][27][28][29][30], however, more extensive and deep-going explorations of this area are still needed. In this study, we evaluated the component variation and excluded the interference of small molecular organic compounds using an HPLC method.…”

Section: Discussionmentioning

confidence: 99%

“…With dramatic properties, such as favourable photoluminescence, excellent chemical stability and hypotoxicity, water dispersity and biocompatibility [9][10][11][12][13][14][15][16][17], CDs has been widely applied in medical domain [18], including drug delivery [19,20], bio-imaging [21,22], optical imaging and sensing [23,24]. Nowadays, researches on self-bioactivity of CDs are on the rise, for example, peroxidase-like activity [25], haemostatic efficacy [26][27][28][29] and selective antibacterial activity against Porphyromonas gingivalis [30], however, more extensive and deep-going explorations of this area are still needed.…”

Section: Introductionmentioning

confidence: 99%

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Haemostatic bioactivity of novel Schizonepetae Spica Carbonisata-derived carbon dots via platelet counts elevation

Sun

Lü

Cheng

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Schizonepetae Spica Carbonisata (SSC) has pronounced haemostatic effects for hundreds of years and has been acknowledged in the 2015 Pharmacopoeia of the People's Republic of China (PPRC) as a haemostatic charcoal drug. However, after years of efforts, the underlying mechanism and the material basis is still less defined. In this research, we developed a novel CDs derived from SSC (SSC-CDs) with an average diameter of 1.29-6.87 nm and a quantum yield of 6.31%. SSC was prepared using a modified pyrolysis method and no further modification and external surface passivation agent is required. With abundant surface groups, SSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used the Deinagkistrodon acutus (D. acutus) venom model as well as the classical haemorrhagic animal model to evaluate the haemostatic bioactivity of SSC-CDs. The results indicated that SSC-CDs had outstanding haemostatic bioactivity and might inhibit the haemorrhagic activity via PLT elevation. According to the results of this study and our previous work, we discovered that CDs derived from different kinds of charcoal drugs presented similarities and differences in the structural feature, physicochemical property and bioactivity. In order to further explore the self-bioactivities, we first named this kind of CDs as "Chinese Medicine charcoal drug nanoparticles" (CMNP). These results may not only provide evidence for further researches of self-bioactivities of CDs but give new insights into potential biomedical and healthcare applications of CDs, therefore, make contributions to future drug discovery.

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Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots

Cited by 75 publications

References 24 publications

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata

Haemostatic bioactivity of novel Schizonepetae Spica Carbonisata-derived carbon dots via platelet counts elevation

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