Hemostatic effect of novel carbon dots derived from <i>Cirsium setosum</i> Carbonisata

Luo, Jian; Zhang, Meiling; Cheng, Jinjun; Wu, Shuhong; Xiong, Wei; Kong, Hui; Zhao, Yan; Qu, Huihua

doi:10.1039/c8ra06340k

Cited by 28 publications

(23 citation statements)

References 31 publications

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“…By research on CDs in charcoal drugs, such as carbonized Schizonepetae Herba, carbonized Cirsii Herba and carbonized Typhae Pollen, it was found that CDs existed in all charcoal drugs and were characterized by high water-solubility, good biocompatibility and low toxicity. In addition, all extracted pure CDs showed a good effect of haemostasis (Luo et al 2018;Zhang et al 2018;Wang, Kong et al 2018). Schizonepetae Herba carbonisata has been used in TCM to treat haemorrhagic diseases for more than 100 years, but little information is available on its haemostatic components and mechanism.…”

Section: Theory Of Carbon Dotsmentioning

confidence: 90%

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A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

Chen

Yang

et al. 2019

Pharmaceutical Biology

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Context: Charcoal of Chinese drugs is a kind of special processing product in Chinese medicine and used for treatment of haemoptysis, hematemesis and haemorrhage in the clinic during ancient times. During carbonizing, significant changes occur in chemical constituents and the efficacy of haemostasis will be enhanced. But the quality control standard of ‘carbonizing retains characteristics’ should be followed. Objective: This review introduces the typical methods of carbonizing, which highlight current research progress on haemostatic substances of charcoal drugs so as to provide a reasonable explanation for the theory of haemostasis treated by charcoal medicine. Methods: English and Chinese literature from 2004 to 2019 was collected from databases including Web of Science, PubMed, Elsevier and CNKI (Chinese). Charcoal drug, chemical constituents, processing, haemostasis and carbon dots were used as the key words. Results: Charcoal drugs mainly play a haemostatic role and the effect can be classified into four types to stop bleeding: removing blood stasis, cooling blood, warming meridians and astringing. Changes in composition lead to changes in pharmacodynamics. Carbonizing methods and basic research on haemostasis material in charcoal drugs have also been summarized. Conclusions: This review summarizes the classification of charcoal drugs and highlights the possible material bases for the haemostatic effect of charcoal drugs in recent years, providing new insights to future research.

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Section: Theory Of Carbon Dotsmentioning

confidence: 90%

“…In addition, all extracted pure CDs showed a good effect of haemostasis (Luo et al. 2018; Zhang et al. 2018; Wang, Kong et al.…”

Section: Modern Research On Bleeding Stopping Of Charcoal Drugsmentioning

confidence: 99%

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

Chen

Yang

et al. 2019

Pharmaceutical Biology

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“…A range of applications has been developed for emerging nanomaterials including drug delivery [26], biological imaging [27], and optical catalysts [28]. NPs have been reported in other TCMs carbonised at high temperature including Pollen Typhae Carbonisata, Cirsium Setosum Carbonisata, Schizonepetae Herba Carbonisata, and Junci Medulla Carbonisata [5,[29][30][31]. The STC-NPs possessed components similar to those of other widely-studied nanoparticles [32,33].…”

Section: Molecules 2019 24 X For Peer Review 7 Of 13mentioning

confidence: 99%

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

et al. 2020

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High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4–2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy.

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“…Researchers have tried to elucidate the small molecule active compounds for the effects of charcoal drugs, and the results have been inconclusive. This situation has promoted studies on CDs generated in the charcoal processing ( Luo et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Chinese Medicinal Herb-Derived Carbon Dots for Common Diseases: Efficacies and Potential Mechanisms

Zhao

et al. 2022

Front. Pharmacol.

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The management of hemorrhagic diseases and other commonly refractory diseases (including gout, inflammatory diseases, cancer, pain of various forms and causes) are very challenging in clinical practice. Charcoal medicine is a frequently used complementary and alternative drug therapy for hemorrhagic diseases. However, studies (other than those assessing effects on hemostasis) on charcoal-processed medicines are limited. Carbon dots (CDs) are quasi-spherical nanoparticles that are biocompatible and have high stability, low toxicity, unique optical properties. Currently, there are various studies carried out to evaluate their efficacy and safety. The exploration of using traditional Chinese medicine (TCM) -based CDs for the treatment of common diseases has received great attention. This review summarizes the literatures on medicinal herbs-derived CDs for the treatment of the difficult-to-treat diseases, and explored the possible mechanisms involved in the process of treatment.

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Hemostatic effect of novel carbon dots derived from Cirsium setosum Carbonisata

Abstract: We discovered novel water-soluble carbon dots from aqueous extracts of Cirsium setosum Carbonisata, which have a remarkable hemostatic effect. The study provides evidence to support the further investigation of considerable potential of carbon dots.

Cited by 28 publications

References 31 publications

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

A review on charred traditional Chinese herbs: carbonization to yield a haemostatic effect

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

Chinese Medicinal Herb-Derived Carbon Dots for Common Diseases: Efficacies and Potential Mechanisms

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