Hemorrhagic Fever with Renal Syndrome, Vietnam

Huong, Vû Thi Quê; Yoshimatsu, Kumiko; Luan, Vu Dinh; Туан, Ле Ван; Nhi, Le Huu Hanh; Arikawa, Jiro; Nguyen, Tran M

doi:10.3201/eid1602.091204

Cited by 15 publications

(9 citation statements)

References 9 publications

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“…Antibody positivity among humans has also been reported in Asian countries including India, Sri Lanka and Vietnam [3,5,7]. In the present study, we found SEOV-positive rodents in Thousand Islands regency of Jakarta in Java Sea, where many ships traffic frequently.…”

Section: Discussionsupporting

confidence: 80%

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

Ibrahim

Shimizu

Yoshimatsu

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne zoonotic disease caused by hantavirus infection. Many HFRS cases have been reported in East Asia and North Europe, while the situation in Southeast Asia remains unclear. In this study, the prevalence of hantavirus infection in rodents and humans in Thousand Islands regency, which is close to the port of Jakarta, one of the largest historic ports in Indonesia, was investigated. A total of 170 rodents were captured in 2005, and 27 (15.9%) of the rodents were antibody-positive against Hantaan virus antigen in an immunofluorescence assay (IFA) and Western blotting. Despite the high prevalence in rodents, human sera collected from 31 patients with fever of unknown origin and 20 healthy volunteers in the islands in 2009 did not show positive reaction to the antigen in IFA. To identify the virus in rodents genetically, a total of 59 rodents were captured in 2009. Sera from the rodents were screened for antibody by ELISA, and lung tissues were subjected to RT-PCR. 20 (33.9%) of the 59 rodents were antibody-positive, and 3 of those 20 rodents were positive for S and M genome segments of hantaviruses. Genetic analysis showed that the viruses belonged to Seoul virus and formed a cluster with those in Vietnam and Singapore. These results suggest that a unique group of Seoul viruses has spread widely in Southeast Asia.

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Section: Discussionsupporting

confidence: 80%

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

Ibrahim

Shimizu

Yoshimatsu

et al. 2013

The Journal of Veterinary Medical Science

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“…The hantavirus genus comprises at least 24 recognized virus species, several of which are pathogenic to humans. Although hantaviruses are known to circulate in Vietnam, few clinical cases have been reported (Huong et al 2010), and the relative scope of the associated disease burden remains poorly characterized. Our study indicated an overall 8.3% hantavirus seroprevalence among the five rodent species tested from southern Vietnam.…”

Section: Discussionmentioning

confidence: 99%

Rodents and Risk in the Mekong Delta of Vietnam: Seroprevalence of Selected Zoonotic Viruses in Rodents and Humans

Cương

Carrique-Mas

Be³

et al. 2015

Vector-Borne and Zoonotic Diseases

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In the Mekong Delta in southern Vietnam, rats are commonly traded in wet markets and sold live for food consumption. We investigated seroprevalence to selected groups of rodent-borne viruses among human populations with high levels of animal exposure and among co-located rodent populations. The indirect fluorescence antibody test (IFAT) was used to determine seropositivity to representative reference strains of hantaviruses (Dobrava virus [DOBV], Seoul virus [SEOV]), cowpox virus, arenaviruses (lymphocytic choriomeningitis virus [LCMV]), flaviviruses (tick-borne encephalitis virus [TBEV]), and rodent parechoviruses (Ljungan virus), using sera from 245 humans living in Dong Thap Province and 275 rodents representing the five common rodent species sold in wet markets and present in peridomestic and farm settings. Combined seropositivity to DOBV and SEOV among the rodents and humans was 6.9% (19/275) and 3.7% (9/245), respectively; 1.1% (3/275) and 4.5% (11/245) to cowpox virus; 5.4% (15/275) and 47.3% (116/245) for TBEV; and exposure to Ljungan virus was 18.8% (46/245) in humans, but 0% in rodents. Very little seroreactivity was observed to LCMV in either rodents (1/275, 0.4%) or humans (2/245, 0.8%). Molecular screening of rodent liver tissues using consensus primers for flaviviruses did not yield any amplicons, whereas molecular screening of rodent lung tissues for hantavirus yielded one hantavirus sequence (SEOV). In summary, these results indicate low to moderate levels of endemic hantavirus circulation, possible circulation of a flavivirus in rodent reservoirs, and the first available data on human exposures to parechoviruses in Vietnam. Although the current evidence suggests only limited exposure of humans to known rodent-borne diseases, further research is warranted to assess public health implications of the rodent trade.

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“…These results indicated that SEOV infection might have spread among rats not only in port areas but also in inland large cities throughout Vietnam. Although serological surveillance among humans in Southern Vietnam is still limited, an HFRS case that was infected with SEOV was reported in HCMC [5]. Thus, further consideration of the status of hantavirus infection is necessary from a public health point of view.…”

Section: Discussionmentioning

confidence: 99%

Studies on Hantavirus Infection in Small Mammals Captured in Southern and Central Highland Area of Vietnam

Luan

Yoshimatsu

Endo

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. To investigate the distribution of hantaviruses among animals in Southern and Central Highland area of Vietnam, a total of 1311 serum samples were obtained from rats and Asian house shrews (Suncus murinus) captured at 11 locations between 2006 and 2009. A total of 1066 serum samples from rats were examined for IgG antibodies against Hantaan virus, and there were 30 antibody-positive serum samples from rats that had been captured mainly in a port area and urban area in Ho Chi Minh City (HCMC) (2.8%). All of the antibody-positive rats were Rattus norvegicus, and they had Seoul virus (SEOV) genome in their lungs. SEOV sequences detected from rats captured in Southern Vietnam belonged to the same lineage as those from rats captured at Haiphong Port and a market area in Hanoi City. SEOV strain CSG5 was isolated from a rat captured at Saigon Harbor. Strain CSG5 showed a cross-neutralization pattern almost the same as that of a representative strain of SEOV. A total of 245 Asian house shrews were captured in the Central Highland area and near HCMC. Sera were examined for IgG antibodies against Thottapalayam virus (TPMV), and 32 (13.1%) of the antibody-positive shrews were mainly from the Central Highland area and showed a neutralizing antibody against TPMV. These results indicated that SEOV is distributed among R. norvegicus inhabiting harbor and urban areas of Southern Vietnam and that TPMV or an antigenically related virus is distributed among Asian house shrews in Central Highland area.

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Hemorrhagic Fever with Renal Syndrome, Vietnam

Cited by 15 publications

References 9 publications

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

Epidemiology of Hantavirus Infection in Thousand Islands Regency of Jakarta, Indonesia

Rodents and Risk in the Mekong Delta of Vietnam: Seroprevalence of Selected Zoonotic Viruses in Rodents and Humans

Studies on Hantavirus Infection in Small Mammals Captured in Southern and Central Highland Area of Vietnam

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