“…There was no obvious fibrinolytic activity to which proteolytic digestion of fibrinogen could be attributed. Nor do we know of any evidence to suggest that the mechanism is the same as that found in premature separation of the placenta (Stevenson et al, 1953) and perhaps in certain lung operations (Chalnot et al, 1952), where it seems that intravascular clotting may take place with consequent depletion of fibrinogen, as a result of the release into the circulation of excessive thromboplastin from the organ involved. The fibrinolytic factor, when it is present, is more easily understood, since tissue juices from a prostatic carcinoma have been shown in vitro to cause clot lysis and also to digest fibrinogen, factor V (ac-globulin), and probably prothrombin (Tagnon et al, 1953a(Tagnon et al, , 1953b.…”