Dangerous Bleeding Associated with Carcinoma of Prostate

Uncontrollable Post-operative Haemorrhage After Incompatible Blood Transfusion

“…It has often been reported that a defect of coagulation may occur in obstetrical conditions and in pulmonary and prostatic surgery. For example, it has been noted in accidental haemorrhage, amniotic fluid embolism, intrauterine foetal death, and missed abortion (De Lee, 1901;Dieckmann, 1936;Moloney et al, 1949;Schneider, 1951 ;Reid et al, 1953;Barry et al, 1955), following pulmonary lobectomy (Soulier et al, 1952), and in metastatic carcinoma of the prostate (Tagnon et al, 1952;Swan et al, 1957). One of the features of these cases has been hypofibrinogenaemia.…”

Verbrauchskoagulopathie bei metastasierendem Prostatakarzinom

“…Allerdings neigen bestimmte Karzinome, wie die Karzinome des Gastrointestinaltraktes [1, 3,5,8], das Prostata karzinom [5,15,16,18,19,21] und das Pankreaskarzinom [5,9] besonders häufig zu dieser Komplikation. Das Prostatakarzinom weist insofern eine Sonderstellung auf, als hier eine Defibrinierung nicht nur durch eine intravaskulärc Gerinnung, sondern auch durch eine Hyperfibrinolyse [10,20] …”

Neoplastic Diseases (Cancer)

“…A hemorrhagic diathesis has been seen occasionally in association with cancer of the prostate and other tumors. In some instances, low fibrinogen due to a proteolysin is at fault (15); in others both proteolysis of fibrinogen and intravascular coagulation are responsible (16); and in one patient careful analysis could find no simple explanation of the clotting defect (17). Another defect in the clotting mech anism of cancer patients is a tendency to the formation of multiple throm boses.…”