“…It has often been reported that a defect of coagulation may occur in obstetrical conditions and in pulmonary and prostatic surgery. For example, it has been noted in accidental haemorrhage, amniotic fluid embolism, intrauterine foetal death, and missed abortion (De Lee, 1901;Dieckmann, 1936;Moloney et al, 1949;Schneider, 1951 ;Reid et al, 1953;Barry et al, 1955), following pulmonary lobectomy (Soulier et al, 1952), and in metastatic carcinoma of the prostate (Tagnon et al, 1952;Swan et al, 1957). One of the features of these cases has been hypofibrinogenaemia.…”