Uncontrollable Post-operative Haemorrhage After Incompatible Blood Transfusion

Moore, James M.

doi:10.1136/bmj.2.5106.1201

Cited by 12 publications

(4 citation statements)

References 9 publications

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“…It has long been recognized that a generalized bleeding diathesis may follow the transfusion of incompatible blood [15]. In the 1950s and 1960s, there appeared numerous case reports of patients suffering from acute hemolytic reactions who demonstrated clear-cut evidence of coagulation disorders [16][17][18]. These disorders were manifested by thrombocytopenia, prolongation of the prothrombin and partial thromboplastin times, hypofibrinogenemia, and the appearance of a circulating heparin-like anticoagulant.…”

Section: Hemolytic Transfusion Reactionsmentioning

confidence: 99%

Analytic Reviews : Hemolytic Transfusion Reactions: A Review of Mechanisms, Sequelae, and Management

Capon

Sacher

1989

J Intensive Care Med

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The transfusion of blood and blood products is an im portant therapeutic procedure, but it is associated with several potentially serious adverse effects. Among these complications are hemalytic reactions, which in most cases result from the interaction between donor red cell antigens and recipient plasma antibodies. Clinical mani festations and sequelae are largely determined by the physical and immunological characteristics of the anti gens and antibodies. Early recognition may be difficult in the anesthetized or intensively monitored patient. Acute hemolytic reactions are responsible for significant morbidity and mortality and may lead to life-threatening shock, disseminated intravascular coagulation, and renal failure. Fortunately, fatal hemolytic transfusion reactions are rare; they usually result from clerical errors. Proper diagnosis and management requires sound clinical judg ment, thorough laboratory investigation, and timely therapeutic intervention.

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Section: Hemolytic Transfusion Reactionsmentioning

confidence: 99%

Analytic Reviews : Hemolytic Transfusion Reactions: A Review of Mechanisms, Sequelae, and Management

Capon

Sacher

1989

J Intensive Care Med

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show abstract

“…Although transfusion of the incompatible blood must be discontinued immediately, it is important t o correct any pre-existing oligaemia by the further transfusion of plasma, albumin, or compatible blood. Dextran should be avoided because of the risk of haemorrhagic complications [15]. If the patient is hypotensive because of the antigen-antibody reaction and is not oligaemic, a vasopressor drug such as methoxamine (10-15 mg intramuscularly) should be injected.…”

Section: Management Of Haemolytic Transfusion Reactionsmentioning

confidence: 99%

Management of Haemolytic Transfusion Reactions

Gh¹

1963

Vox Sanguinis

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“…Although transfusion of the incompatible blood must be discontinued immediately, it is important to correct any pre-existing oligaemia by the further transfusion of plasma, albumin, or compatible blood. Dextran should be avoided because of the risk of haemorrhagic complications [15]. If the patient is hypo tensive because of the antigen-antibody reaction and is not oligaemic, a vasopressor drug such as methoxamine (10-15 mg intramuscularly) should be injected.…”

Section: Editorialmentioning

confidence: 99%

“…Many haematologists have ex perience of one or more cases in which the transfusion of as much as 400 ml of ABO-incompatible blood has resulted in the recipient suf fering little more than an episode of haemoglobinuria and a transient jaundice. More often, however, the in vivo antigen-antibody reaction results in a shock-like state, which is usually followed by acute renal failure and exceptionally is complicated by abnormal bleeding with afibrinogenaemia and fibrinolysis [17,10,15].…”

Section: Editorialmentioning

confidence: 99%