Hemorheological disturbances, metabolic parameters and blood pressure in different types of obesity

Wysocki, Marian; Krotkiewski, M; Braide, Magnus; Bagge, U.

doi:10.1016/0021-9150(91)90253-y

Cited by 27 publications

(28 citation statements)

References 34 publications

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“…24 The increased RCA in the overweight (Figure 1) as compared with a subset of the Third north Glasgow MONICA survey population is in agreement with previous studies in overweight NIDDM, 9 adults and children. 11,29,30 The overall 13% reduction achieved in this study is comparable with the results of other studies in healthy overweight subjects. 11 The association between reduced abdominal fat distribution and RCA could suggest a mechanism related to insulin resistance.…”

Section: Discussionsupporting

confidence: 88%

“…5,10,41 An elevated PAI activity has been associated with obesity and with raised WHR. 5,30 Signi®cant reductions in PAI-1 and t-PA antigen have been shown after weight loss 5,10,42 which are double that observed in this present study. The reason for a reduction in t-PA antigen but not PAI activity in female subjects in our study is unclear.…”

Section: Discussionsupporting

confidence: 69%

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Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

et al. 1997

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OBJECTIVE: To investigate the effect of a dietary intervention to reduce body weight on red cell aggregation (RCA), factor VII activity, plasminogen activator inhibitor (PAI) activity, tissue plasminogen activator (t-PA) antigen, ®brino-gen, whole blood and plasma viscosity, haematocrit and lipids. DESIGN: Open single stranded study of dietary intervention for weight loss in a volunteer sample. SUBJECTS: Forty-®ve subjects whose BMI exceeded 26 kgam 2 were recruited and received dietetic advice designed to reduce body weight by 0.5 kg per week. MEASUREMENTS: Body weight and waist and hip circumferences, dietary intake by seven day weighed inventory, RCA, factor VII activity, PAI activity, t-PA antigen, ®brinogen, whole blood and plasma viscosity, haematocrit and lipids. RESULTS: After 12 weeks of dietary intervention there were reductions in body weight and BMI by 5.9 (s.d. 3.3) kg and 1.9 (s.d. 1.0) kgam 2 respectively in males, and 4.1 (s.d. 2.9) kg and 1.6 (s.d. 1.1) kgam 2 in females (P`0.0001). Factor VII activity (P 0.0043), RCA (P 0.01) and t-PA antigen (P 0.016) were reduced in females after weight reduction but no differences were found in PAI activity, whole blood, plasma viscosity or haematocrit. The changes in factor VII activity and RCA were appropriate for the changes in BMI on the basis of the relationships of the risk factors with BMI in a cross sectional survey of a representative Scottish population. Plasma total cholesterol was reduced (P 0.016) but HDL cholesterol and triglycerides remained unchanged. There were signi®cant associations between the reductions in factor VII activity and BMI (r 0.395, P 0.013) and between the reductions in RCA and waist to hip ratio (r 0.350, P 0.04). No relationship was seen between changes in serum cholesterol and changes in factor VII activity or RCA. CONCLUSIONS: Modest weight loss, of 5% body weight, with conventional dietary intervention reduces two established risk factors for ischaemic heart disease (factor VII activity and RCA) which are generally elevated in those with increased body weight.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 69%

Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

et al. 1997

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“…Because of the presence of different degrees of obesity and diverse methodologies, contradictory results have been published regarding RBC deformability in obese patients. [166][167][168][169] Some studies describe an increase in membrane cholesterol/phospholipid ratio, whereas only one study involved patients with morbid obesity. [170][171][172][173] A recent study focused on the evaluation of RBC deformability in a group of patients with severe and morbid obesity without other cardiovascular risk factors.…”

Section: Obesitymentioning

confidence: 99%

Biomechanical properties of red blood cells in health and disease towards microfluidics

2014

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Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to navigate across various human microcirculation vessels, enabling them to pass through capillaries that are smaller than their diameter and to carry out their role as gas carriers between blood and tissues. Since there is growing evidence that red blood cell deformability is impaired in some pathological conditions, measurement of RBC deformability has been the focus of numerous studies over the past decades. Nevertheless, reports on healthy and pathological RBCs are currently limited and, in many cases, are not expressed in terms of well-defined cell membrane parameters such as elasticity and viscosity. Hence, it is often difficult to integrate these results into the basic understanding of RBC behaviour, as well as into clinical applications. The aim of this review is to summarize currently available reports on RBC deformability and to highlight its association with various human diseases such as hereditary disorders (e.g., spherocytosis, elliptocytosis, ovalocytosis, and stomatocytosis), metabolic disorders (e.g., diabetes, hypercholesterolemia, obesity), adenosine triphosphate-induced membrane changes, oxidative stress, and paroxysmal nocturnal hemoglobinuria. Microfluidic techniques have been identified as the key to develop state-of-the-art dynamic experimental models for elucidating the significance of RBC membrane alterations in pathological conditions and the role that such alterations play in the microvasculature flow dynamics. V C 2014 AIP Publishing LLC.

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“…Plazma fibrinojeninin kardiyovasküler hastalıklar için bağımsız bir risk faktörü olduğu ve plazma fibrinojen dü-zeyinin kanın viskozitesinden sorumlu temel faktörlerden olduğu birçok çalışmada ortaya konulmuştur. Obezlerde diğer risk faktörlerine ilaveten, plazma fibrinojen düzey-lerinde de artma olmaktadır ve obezitenin düzeltilmesiyle bu artışta azalma olduğu gösterilmiştir [32]. Yönem ve ark.…”

Section: Discussionunclassified

“…Obezlerde diğer risk faktörlerine ilaveten, plazma fibrinojen düzeylerinde de artma olmaktadır ve obezitenin düzeltil-mesiyle fibrinojen düzeyinin azaldığı gösterilmiştir [3]. İnsülin direnci; endojen ya da eksojen insülinin periferik dokularda yeterli glukoz alımını ve kullanımını sağlaya-mamasıdır.…”

Section: Introductionunclassified

The Relationship Between Insulin Resistance and Leptin, Interleukin-6, hs-CRP and Fibrinogen in Obese and Non-Obese Individuals

Koçak¹,

Kutlu²,

Çivi³

et al. 2014

Turk J Bioch

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Objective: Obesity is still an actual subject because of its rapidly increasing prevalence. Although it is not a serious disease by itself, obesity plays an important role in the development of diabetes mellitus and cardiovasculer diseases. In this study, we aimed to investigate the relationship between insulin resistance and interleukin-6, leptin, hs-CRP and fibrinogen in obese and non-obese individuals. Methods: This study, which is an analytical study in the case-control type, was conducted on 329 adult individuals. Heights, weights, body mass indexes (BMI), waist circumferences, blood pressures, fasting blood glucose (FBG), total cholesterol, triglyceride, LDL-c, HDL-c, hs-CRP, leptin, IL-6, fibrinogen, and insulin levels were measured. Results: Of all the participants, 204 (62.0%) were female, 125 (38.0%) were male; 71 of them were of (21.5%) normal weight, 89 (27.1%) were overweight and 169 were (51.4%) obese. There was a significant correlation between low educational level and obesity (p<0.001). The married participants exhibited higher rates of being overweight and obese than other groups (p<0.001). There was a significant relationship between FBG, TG, HDL-c levels in male/female gender and BMI, statistically (p<0.05). In our study, a significant correlation was found between insulin, insulin resistance, hs-CRP, fibrinogen, leptin levels, low HDL-c levels and obesity (p<0.05). No statistically significant relationship was found between IL-6 and obesity (p>0.05). As a result of the multiple regression analysis, HOMA-IR, leptin ve hs-CRP levels was found as the effective basic factors on obesity. On the other hand, there was a significant relationship between high blood pressure and obesity (p<0.001). Conclusion: In our study, high fasting blood glucose, TG, insulin, insulin resistance, hs-CRP, fibrinogen, leptin and low HDL-c levels were found to be correlated with obesity. This correlation leads to many diseases, notably diabetes mellitus and cardio-vascular diseases. Key Words: Fibrinogen, hs-CRP, IL-6, insulin resistance, leptin, obesity. Conflict of Interest:The authors declare no conflict of interest. ÖZETAmaç: Obezite, dünyadaki hızlı prevalans artışı nedeniyle güncelliğini korumakta olan bir konudur. Tek başına ciddi bir hastalık olmamasına rağmen, diabetes mellitus ve kardiyovasküler hastalıkların gelişmesinde önemli bir rol oynar. Bu çalışmada obez olan ve olmayan bireylerde insülin direnci ile interlökin-6 (IL-6), leptin, hs-CRP ve fibrinojen ilişkisini araştırmayı amaç-ladık. Metod: Vaka kontrol tipinde analitik bir araştırma olan bu çalışma 329 erişkin bireyde gerçekleştirildi. Boy, kilo, bel çevresi, kalça çevresi, kan basınçları, açlık plazma glukozu (APG), total kolesterol, trigliserit (TG), LDL-c, HDL-c, hs-CRP, leptin, IL-6, fibrinojen, açlık insülin düzeyleri ölçüldü. Bulgular: Katılanların 125'i (%38.0) erkek, 204'ü (%62.0) kadındı, 71'i (%21.5) normal kilolu, 89'u (%27.1) fazla kilolu, 169'u (%51.4) obez idi. Düşük eğitim düzeyi ile obezite anlamlı bir ilişki göstermekte idi (...

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Hemorheological disturbances, metabolic parameters and blood pressure in different types of obesity

Cited by 27 publications

References 34 publications

Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

Moderate weight reduction improves red cell aggregation and factor VII activity in overweight subjects

Biomechanical properties of red blood cells in health and disease towards microfluidics

The Relationship Between Insulin Resistance and Leptin, Interleukin-6, hs-CRP and Fibrinogen in Obese and Non-Obese Individuals

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