Hemorheologic profile in healthy women undergoing controlled ovarian stimulation

Fatini, C.; Mannini, Lucia; Sticchi, Elena; Milanini, Maria Novella; Cioni, Gabriele; Liotta, Agatina Alessandrello; Abbate, Rosanna; Noci, Ivo

doi:10.1016/j.fertnstert.2010.07.1078

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…29,57,58 Evidence has also been accruing in support of a further rightward shift in the prothrombotic state generated by COH in women who have an elevated body mass index (BMI). 51,57 Similar changes of the coagulation and fibrinolytic systems have likewise been noted during OHSS. 59,60 Investigations utilizing thromboelastography (TEG), which enables representation of the elastic qualities of blood, and offers a comprehensive appraisal of its hemostatic function, similarly support assertions of amplified coagulability during COH 53,55,61,62 that may persist well beyond the time of its completion.…”

Section: Assisted Reproductive Technology and Thrombophilia Controlled Ovarian Hyperstimulation And Altered Hemostasissupporting

confidence: 60%

“…1, ►Table 2). Specifically, investigators have established that COH is accompanied by a shift to a procoagulant milieu, 29,[49][50][51] whereby parameters influencing coagulation are upregulated, [52][53][54] while determinants of fibrinolysis remain largely unchanged, [52][53][54][55][56] or perhaps even downregulated. 29,57,58 Evidence has also been accruing in support of a further rightward shift in the prothrombotic state generated by COH in women who have an elevated body mass index (BMI).…”

Section: Assisted Reproductive Technology and Thrombophilia Controlled Ovarian Hyperstimulation And Altered Hemostasismentioning

confidence: 99%

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The Pathophysiology of Hypercoagulability and Infertility

Malinowski

2021

Semin Reprod Med

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Alongside an interplay of a multitude of factors, attainment of a favorable pregnancy outcome is predicated on successful implantation, which in itself is a complex process anchored by balanced interchange with the hemostatic system. Among other etiologies, failure of implantation can result in infertility, and lead affected couples to consider assisted reproductive technology (ART) in an effort to fulfill their desire for procreation. Given the critical role of the hemostatic system in the process of implantation, documentation of a hypercoagulable state during controlled ovarian stimulation in the context of in vitro fertilization, as well as the potential association of its derangement in the setting of thrombophilia, with infertility, ART, ovarian hyperstimulation syndrome, and failure of implantation are explored. Additionally, current evidence addressing the relationship between ART and thromboembolism is examined, as is the role of therapy with heparin and aspirin to decrease thrombotic risk and improve ART-related pregnancy outcomes. Evidence-based recommendations from relevant professional societies are summarized.

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Section: Assisted Reproductive Technology and Thrombophilia Controlled Ovarian Hyperstimulation And Altered Hemostasissupporting

confidence: 60%

Section: Assisted Reproductive Technology and Thrombophilia Controlled Ovarian Hyperstimulation And Altered Hemostasismentioning

confidence: 99%

The Pathophysiology of Hypercoagulability and Infertility

Malinowski

2021

Semin Reprod Med

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“…1,2 Therefore fertility therapy may represent a sex-specific atherothrombotic risk factor, in particular in women at an advanced age (>40 yrs) undergoing oocyte donation procedures. Hormonal fertility treatment is associated with a procoagulant milieu by increasing coagulation factors, reducing fibrinolysis, and altering rheological parameters; 3,4 this status is comparable with that observed in women who conceived spontaneously. It is well known that Assisted Reproduction procedures confer a risk of venous thromboembolism, although the absolute magnitude is quite low.…”

Section: To the Editormentioning

confidence: 81%

Factors VIII and von Willebrand levels in women undergoing Assisted Reproduction: are their levels associated with clinical pregnancy outcome?

Attanasio

Cirillo

Coccia

et al. 2020

Mediterr J Hematol Infect Dis

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A growing number of infertile women are considering pregnancy through assisted reproductive technologies; hormonal fertility treatment is associated with a procoagulant milieu. In oocyte donation Assisted Reproductive Technologies there are patients who experience repeated implantation failures, as well as biochemical pregnancy, in particular in women at advanced age (>40 yrs). No information is available concerning coagulation changes in women undergoing oocyte donation. In this study, we decided to identify changes in haemostasis in women undergoing infertility treatment and their relationship with clinical pregnancy outcome. Our findings evidence an early increase of FVIII and VWF coagulation proteins, suggesting their potential role as early “predictors” of a successful clinical pregnancy in oocyte donation women. This may be intriguing for exploring potential mechanisms responsible for the establishment of a successful pregnancy after oocyte donation.

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