Fibrinolysis alterations in infertile women during controlled ovarian stimulation: Influence of BMI and genetic components

Sticchi, Elena; Romagnuolo, Ilaria; Cellai, Anna Paola; Lami, Donatella; Fedi, Sandra; Prisco, Domenico; Noci, Ivo; Abbate, Rosanna; Fatini, C.

doi:10.1016/j.thromres.2012.07.005

Cited by 10 publications

(6 citation statements)

References 27 publications

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“…It has been reported that there is also an association between elevated levels of SERPINE1 expression in the blood and increased risk for infertility and a worse pregnancy outcome (Ye et al, ). Although observations in alteration levels of SERPINE1 in women undergoing COS (Chan, ; Sticchi et al, ) are contradictory, many studies have suggested that there is an activation of coagulation and fibrinolysis systems in patients with ovarian stimulation. This activation is highly emphasized in the development of OHSS (Chan, ).…”

Section: Discussionmentioning

confidence: 99%

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Ghaderian

Akbarzadeh

Mohajerani

et al. 2019

Molecular Reproduction Devel

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Ovarian hyperstimulation syndrome (OHSS) is an undesirable complication in the course of ovarian stimulation. This kind of stimulation is aimed at acquiring a sufficient number of high‐quality oocytes in in vitro fertilization (IVF). Whereas the predisposition to OHSS could be impacted by genetic polymorphisms in susceptible genes, the present study has been jointly conducted with an Iranian cohort to scrutinize its relevant implication. Genomic DNA was extracted from blood samples of patients with a normal ovarian response (NOR) or with OHSS. Samples were analyzed to detect polymorphisms MTHFR rs1801131, MTHFR rs1801133, AMHR2 rs2002555, LHCGR rs2293275, PGR rs10895068, and SERPINE1 rs1799889. Variations of MTHFR, AMHR2, LHCGR, and PGR genes were significantly associated with the developing OHSS. After correction for multiple analysis, this difference was not evident for PGR genotypes. The polymorphic alleles of MTHFR (rs1801131 C‐allele and rs1801133 T‐allele), AMHR2 (rs2002555 G‐allele), and LHCGR (rs2293275 G‐allele) were significantly more prevalent among patients with OHSS compared to those in the NOR group. In contrast, the minor allele of PGR single‐nucleotide polymorphism (SNP) (rs10895068, A‐allele) was more prominent among patients with a NOR than those with OHSS. No significant difference was observed in genotypes or alleles of SERPINE1 rs1799889. The observations indicated that the minor alleles of MTHFR, AMHR2, and LHCGR genes could be considered an independent risk factor in susceptibility to OHSS. Nevertheless, polymorphic allele in the PGR rs10895068 SNP contributes to preventing OHSS occurrence. Therefore, it can be argued that these genes have a significant impact on OHSS.

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Section: Discussionmentioning

confidence: 99%

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Ghaderian

Akbarzadeh

Mohajerani

et al. 2019

Molecular Reproduction Devel

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“…1,2 Therefore fertility therapy may represent a sex-specific atherothrombotic risk factor, in particular in women at an advanced age (>40 yrs) undergoing oocyte donation procedures. Hormonal fertility treatment is associated with a procoagulant milieu by increasing coagulation factors, reducing fibrinolysis, and altering rheological parameters; 3,4 this status is comparable with that observed in women who conceived spontaneously. It is well known that Assisted Reproduction procedures confer a risk of venous thromboembolism, although the absolute magnitude is quite low.…”

Section: To the Editormentioning

confidence: 84%

Factors VIII and von Willebrand levels in women undergoing Assisted Reproduction: are their levels associated with clinical pregnancy outcome?

Attanasio

Cirillo

Coccia

et al. 2020

Mediterr J Hematol Infect Dis

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A growing number of infertile women are considering pregnancy through assisted reproductive technologies; hormonal fertility treatment is associated with a procoagulant milieu. In oocyte donation Assisted Reproductive Technologies there are patients who experience repeated implantation failures, as well as biochemical pregnancy, in particular in women at advanced age (>40 yrs). No information is available concerning coagulation changes in women undergoing oocyte donation. In this study, we decided to identify changes in haemostasis in women undergoing infertility treatment and their relationship with clinical pregnancy outcome. Our findings evidence an early increase of FVIII and VWF coagulation proteins, suggesting their potential role as early “predictors” of a successful clinical pregnancy in oocyte donation women. This may be intriguing for exploring potential mechanisms responsible for the establishment of a successful pregnancy after oocyte donation.

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“…Specifically, investigators have established that COH is accompanied by a shift to a procoagulant milieu, 29,[49][50][51] whereby parameters influencing coagulation are upregulated, [52][53][54] while determinants of fibrinolysis remain largely unchanged, [52][53][54][55][56] or perhaps even downregulated. 29,57,58 Evidence has also been accruing in support of a further rightward shift in the prothrombotic state generated by COH in women who have an elevated body mass index (BMI). 51,57 Similar changes of the coagulation and fibrinolytic systems have likewise been noted during OHSS.…”

Section: Controlled Ovarian Hyperstimulation and Altered Hemostasismentioning

confidence: 99%

“…29,57,58 Evidence has also been accruing in support of a further rightward shift in the prothrombotic state generated by COH in women who have an elevated body mass index (BMI). 51,57 Similar changes of the coagulation and fibrinolytic systems have likewise been noted during OHSS. 59,60 Investigations utilizing thromboelastography (TEG), which enables representation of the elastic qualities of blood, and offers a comprehensive appraisal of its hemostatic function, similarly support assertions of amplified coagulability during COH 53,55,61,62 that may persist well beyond the time of its completion.…”

Section: Controlled Ovarian Hyperstimulation and Altered Hemostasismentioning

confidence: 99%

The Pathophysiology of Hypercoagulability and Infertility

Malinowski

2021

Semin Reprod Med

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Alongside an interplay of a multitude of factors, attainment of a favorable pregnancy outcome is predicated on successful implantation, which in itself is a complex process anchored by balanced interchange with the hemostatic system. Among other etiologies, failure of implantation can result in infertility, and lead affected couples to consider assisted reproductive technology (ART) in an effort to fulfill their desire for procreation. Given the critical role of the hemostatic system in the process of implantation, documentation of a hypercoagulable state during controlled ovarian stimulation in the context of in vitro fertilization, as well as the potential association of its derangement in the setting of thrombophilia, with infertility, ART, ovarian hyperstimulation syndrome, and failure of implantation are explored. Additionally, current evidence addressing the relationship between ART and thromboembolism is examined, as is the role of therapy with heparin and aspirin to decrease thrombotic risk and improve ART-related pregnancy outcomes. Evidence-based recommendations from relevant professional societies are summarized.

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Fibrinolysis alterations in infertile women during controlled ovarian stimulation: Influence of BMI and genetic components

Cited by 10 publications

References 27 publications

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

Factors VIII and von Willebrand levels in women undergoing Assisted Reproduction: are their levels associated with clinical pregnancy outcome?

The Pathophysiology of Hypercoagulability and Infertility

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