Hemoplazmozlu Kedi̇lerde Bazi Kan Gazi, Hemogram Ve Bi̇yoki̇myasal Parametreleri̇n Değerlendi̇ri̇lmesi̇

Abstract

The aim of the presented study was to evaluate some blood gas, hemogram, and biochemical parameters in cats with hemoplasmosis. Ten healthy and fifteen cats with hemoplasmosis were enrolled in the study. 7 mL of blood sample was taken once from all cats included in the study into tubes with and without anticoagulant. Blood gas, complete blood count, and biochemical analyzes were performed from blood samples. While pH and HCO3 levels of cats with hemoplasmosis were significantly lower than healthy cats, lactate and BE levels were higher (p< 0.05). WBC, MON, GRA and RDW levels were found to be significantly higher than in healthy cats, while RBC, HCT, Hb, and PLT levels were found to be lower (p< 0.05). AST, TBIL, DBIL, P, TRI, LDH, TP, and CPK levels were significantly higher than healthy subjects, while ALB and Ca levels and A:G ratio were found to be low (p< 0.05). As a result, significant changes occur in blood gas, complete blood count, and biochemical parameters of cats with hemoplasmosis. In addition, it was concluded that the A:G ratio should be considered in the diagnosis of cats with hemoplasmosis and that it should be evaluated together with other diagnostic test results.

Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis

“…It has also been reported that Plasmodium -infected erythrocytes produce up to 100 times more lactate than uninfected erythrocytes 28 . In the present study, hyperlactatemia and mild metabolic acidosis in cats with feline hemotropic mycoplasmosis may be attributed to a decrease in tissue perfusion due to anemia 25 , 26 and an increase in lactate production by infected erythrocytes 26 , 28 .…”

“…There is a paucity of information regarding the evaluation of blood gas analysis in cats with feline hemotropic mycoplasmosis. İder et al 25 reported that metabolic acidosis and hyperlactatemia developed in cats with hemotropic mycoplasmosis. Studies in anemic patients infected with Plasmodium species have reported that systemic hypoxia due to anemia may lead to an increase in anaerobic glycolysis, higher lactate production, and lactic acidosis 26 .…”

“…Changes in the leukocyte panel in cats with feline hemotropic mycoplasmosis have been reported to be highly variable and of limited diagnostic value 2 , 29 . On the other hand, it has been reported that infected cats may develop a total leukocyte increase 2 , 25 , monocytosis, and in some cases lymphocytosis 30 . In the present study, the increase in total leukocyte count, granulocytosis, monocytosis, and lymphocytosis in cats with hemoplasmosis was interpreted as an indicator of inflammation due to infection in consistency with previous studies 2 , 25 .…”

“…On the other hand, it has been reported that infected cats may develop a total leukocyte increase 2 , 25 , monocytosis, and in some cases lymphocytosis 30 . In the present study, the increase in total leukocyte count, granulocytosis, monocytosis, and lymphocytosis in cats with hemoplasmosis was interpreted as an indicator of inflammation due to infection in consistency with previous studies 2 , 25 . In addition, macrocytic and hypo/normochromic regenerative anemia due to hemolysis are among the most common findings in cats with hemotropic mycoplasmosis 1 , 31 .…”

“…In the present study, the increased total and direct bilirubin concentrations in cats with feline hemotropic mycoplasmosis were interpreted as excessive bilirubin production due to intravascular and extravascular hemolysis and exceeding hepatic bilirubin clearance capacity 35 . In addition, the high AST and LDH enzyme activities determined in cats with hemotropic mycoplasmosis may be related to hemolysis, and the high phosphorus levels may be related to the release of excessive amounts of phosphorus from erythrocytes as a result of intravascular hemolysis 25 .…”