Hemophagocytic syndrome: A cause for fatal outcome in tuberculosis

Gupta, Anupama P; Parate, Sanjay N; Bobhate, S. K.; Anupriya, -

doi:10.4103/0377-4929.48939

Cited by 13 publications

(12 citation statements)

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“…1, 2). All the above findings raised a strong suspicion of hemophagocytic syndrome which was affirmatively confirmed by the raised levels of serum ferritin (2,221.55 mcg/L), serum triglycerides (251 mg/dL), serum LDH (850 IU/L) and decreased fibrinogen level (1.3 g/L).…”

Section: Case Reportmentioning

confidence: 71%

Hemophagocytic Syndrome

Owaidah

Khalil²,

Mustafa³

et al. 2020

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Section: Case Reportmentioning

confidence: 71%

Hemophagocytic Syndrome

Owaidah

Khalil²,

Mustafa³

et al. 2020

Definitions

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show abstract

“…A paediatric case of tuberculosis-associated HLH was described by Balasubramanian et al 7; the infant in question received intravenous immunoglobulin as well as antitubercular drugs, but did not survive. Another case of tuberculosis with HLH was reported by Gupta et al 8 This patient received dexamethasone along with antitubercular drugs and survived. Pertinently, the patient suffered only mild pancytopenia, and liver function was unaffected, permitting immediate institution of first-line antitubercular drugs.…”

Section: Discussionmentioning

confidence: 90%

Disseminated tuberculosis presenting with secondary haemophagocytic lymphohistiocytosis and Poncet's disease in an immunocompetent individual

et al. 2013

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We report a 27-year-old previously healthy man, who presented with fever and painful swelling of both ankles for 6 months, and who had been jaundiced for 1 week. Clinical examination revealed diffuse macular rash, severe pallor, deep icterus, generalised lymphadenopathy and hepatosplenomegaly. Detailed evaluation revealed granulomata in bone marrow aspirate, and numerous acid fast bacilli in lymph node biopsy. Bone marrow PCR was also positive forMycobacterium tuberculosis. A diagnosis of disseminated tuberculosis was made and antitubercular therapy was initiated. Investigation also showed features of haemophagocytosis within the bone marrow. Results of further tests satisfied the criteria for haemophagocytic lymphohistiocytosis, probably secondary to tuberculosis. However, rapid deterioration in his clinical condition led to his death within 5 days of diagnosis, before appropriate therapy for haemophagocytic lymphohistiocytosis could be instituted. This case report highlights an unusual and deadly presentation of tuberculosis in an immunocompetent individual.

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“…In addition to this case, we reviewed another 10 cases reported in the English literature of subjects under 20 years of age with tuberculosis-associated HPS (Table 2) (4,7-14). In these cases, only two died, one of whom did not receive antituberculous therapy.…”

Section: Discussionmentioning

confidence: 99%

Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review

et al. 2017

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We herein report a rare case of miliary tuberculosis-associated hemophagocytic syndrome (HPS) complicated with respiratory failure. A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital. After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma. In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with hemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis. Therefore, a diagnosis of miliary tuberculosis-associated HPS was made. The patient was successfully treated with antituberculous therapy.

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Hemophagocytic syndrome: A cause for fatal outcome in tuberculosis

Cited by 13 publications

References 0 publications

Hemophagocytic Syndrome

Hemophagocytic Syndrome

Disseminated tuberculosis presenting with secondary haemophagocytic lymphohistiocytosis and Poncet's disease in an immunocompetent individual

Miliary Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review

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