Hemophagocytic lymphohistiocytosis associated with hepatocellular carcinoma

Nagao, Munemasa; Fukuda, Akira; Tsujimura, Marina; Nishioka, Yasuyuki; Umeda, Makoto; Matsumura, Takeshi; Seno, Hiroshi

doi:10.1007/s12328-023-01813-x

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2023

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“…9 HLH is triggered by inborn errors of metabolism, infections, or malignancy. [10][11][12] There are multiple diseases that can mimic the clinical manifestations of HLH, such as idiopathic multicentric Castleman's disease. 13 The main clinical manifestations of HLH are unremitting high fever, pancytopenia, liver/splenomegaly, and other types of organomegaly, liver dysfunction, coagulopathy, and elevation of typical HLH biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Repeated pulmonary nodules as the primary symptom of familial hemophagocytic lymphohistiocytosis in adults: a case report and review

Zhang,

Dong,

et al. 2023

J Int Med Res

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Pulmonary nodules are usually considered to be associated with malignant tumors and benign lesions, such as granuloma, pulmonary lymph nodes, fibrosis, and inflammatory lesions. Clinical cases of pulmonary nodules associated with hemophagocytic lymphohistiocytosis have rarely been reported. Therefore, when patients develop pulmonary nodules, the possibility of developing hemophagocytic lymphohistiocytosis is often not considered. We report the first case of familial hemophagocytic lymphohistiocytosis with recurrent pulmonary nodules as the first symptom. Our findings will hopefully provide new ideas for the diagnosis and treatment of pulmonary nodules in the future.

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