Hemolytic-Uremic Syndrome

Fiorino, Elizabeth K.; Raffaelli, Ryan M.

doi:10.1542/pir.27-10-398

Cited by 9 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E. coli O157:H7 is an enterohemorrhagic strain most commonly associated with hemolytic uremic syndrome (HUS). Roughly 90% of the cases occur in children and the remainder in adults [8,9]. To our knowledge, there is only one previously reported case of neonatal HUS [10].…”

Section: Discussionmentioning

confidence: 92%

Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

et al. 2009

View full text Add to dashboard Cite

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the neonate. NEC is predominantly seen in premature infants; however, in rare instances it can affect full-term infants as well. Although the pathogenesis of NEC remains elusive, it is well established that bacterial colonization is required for development of this disease. In this report, we present a case of a full-term infant, who developed a very aggressive form of NEC and was found to have Escherichia coli (E. coli) O157:H7 both in stool and blood cultures. Unfortunately, despite aggressive surgical and intensive care management, this infant suffered pan-intestinal necrosis and expired. We were not able to establish the route of transmission. To our knowledge, this is the first report of the association of E. coli O157:H7 with NEC.

show abstract

Section: Discussionmentioning

confidence: 92%

Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

et al. 2009

View full text Add to dashboard Cite

show abstract

“…El tratamiento dialítico disminuyó en el último periodo de observación comparado con el previo, debido probablemente al incremento de las formas no oligúricas de IRA (31,32) . La tasa de letalidad promedio fue de 2.2%, similar a lo reportado en otras series (14,15,26) . El elevado porcentaje de coprocultivos negativos observados, se debe a que la gran mayoría recibieron tratamiento antibiótico previo.…”

Section: Discussionunclassified

Epidemiología y Clínica del Síndrome Urémico Hemolítico (SUH). Análisis de tres períodos de observación

Sakihara,

Mansilla,

Valdivia

et al. 2012

Rev Peru Pediatr

View full text Add to dashboard Cite

Objetivos: Estudio descriptivo retrospectivo y longitudinal de pacientes con diagnóstico de Síndrome Urémico hemolítico (SUH) en el INSN, realizado en tres períodos para: Obtener información sobre la situación epidemiológica en nuestro medio.Analizar si el comportamiento clínico demográfico, terapéutico, Tasa de Incidencia Hospitalaria (TIH) y morbimortalidad, han variado en 412 pacientes. Métodos: Se revisan y actualizan los aspectos clínicos y epidemiológicos de 412 pacientes con diagnóstico de SUH, hospitalizados en el Servicio de Nefrología del INSN (1976 – 2009), vistos en tres periodos de tiempo según métodos estadísticos señalados: 1976 - 1996 (20, 22), 1997 - 2001 (31), 2002 – 2009 ( 32). Resultados: La Tasa de Incidencia Hospitalaria (TIH) se ha incrementado significativamente durante los tres periodos. Hay ligero predominio en el sexo masculino (S.M) en los dos últimas periodos y el grupo etario predominante fue el de los menores de 24 meses. La mayoría procedieron de Lima y Callao. Se observó un incremento de pacientes procedentes del interior del país en el último periodo. Primavera y verano fueron las estaciones de mayor frecuencia en los tres periodos del estudio. En los tres periodos hubo pródromo de diarrea en > 95%, así como disentería en más de 2/3 de los casos. La insuficiencia renal aguda (IRA) oligúrica ha disminuido en el último periodo y el tratamiento dialítico se realizó en el 29%, 56% y 46% respectivamente. La presentación de la triada clínica de SUH se incrementó de 59% a 79% en el último periodo. La hipertensión arterial (HTA), convulsiones y edema se observaron en porcentajes similares en los tres periodos. De los coprocultivos realizados, éstos fueron negativos en más del 85%. La letalidad fue 2.2%. En el último periodo hubo 2 casos de SUH familiar autosómico dominante. Conclusiones: La Tasa de Incidencia Hospitalaria (TIH) se ha incrementado sustancialmente durante los tres periodos del estudio. La edad de presentación más frecuente es en menores de dos años, con ligero predominio en el SM en las dos últimas fases. Se presenta en todos los meses con una tendencia bimodal (primavera–verano), en todo el tiempo de observación. La variedad clínica predominante fue del tipo epidérmico (excepto los dos casos familiares). En la tercera fase del estudio se observa incremento de pacientes del interior del país (15%), aumento de la forma no oligúrica de IRA (39%) y presencia de dos casos de SUH familiar autosómico dominante. La letalidad fue de 2.2%.

show abstract

“…At the age of 2, he had cerebral infarction due to hemolytic uremic syndrome (HUS) following Escherichia coli O-157 infection [44]. HUS involves microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency [45]. Many affected individuals develop HUS due to shiga-toxin-producing strains of Escherichia coli, most often the O157:H7 subtype [45].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…HUS involves microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency [45]. Many affected individuals develop HUS due to shiga-toxin-producing strains of Escherichia coli, most often the O157:H7 subtype [45]. Neurological complications of HUS vary between seizures, alteration of consciousness and coma, transient or permanent hemiparesis, and subarachnoid hemorrhage [46].…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

Untitled

2020

JSCR

View full text Add to dashboard Cite

As the gestational age at birth decreases, the risk of the infant having CP increases [6]. Detections of CP among premature births are mostly found through white matter damage on brain-imaging modalities [6]. Evidence of single or multiple brain lesions or ventriculomegaly in a pre-term infant leads to a 50% risk of developing CP [6]. The prenatal Abstract Cerebral palsy (CP) is a neurodevelopmental disorder that hinders normal motor activity and muscle coordination. CP typically appears before, during, or soon after birth as the brain is still developing. The severity of this multifactorial condition depends on the damage done to the parts of the brain that control muscle tone and body movement. The insult in the underdeveloped brain prohibits normal growth; neurons and oligodendrocytes will either die or fail to develop, and the white matter tracts that connect various brain regions become malfunctional. Cerebral palsy is classified into different types depending on the areas of the brain that were insulted and the nature of the movement disorder: spasticity, dyskinesia, and ataxia. Abnormal brain development in patients with CP cannot be reversed, but various treatments are shown to improve and normalize the symptoms. Stem cell transplantation, a regenerative therapy that can replace the damaged and non-functional cells of the brains in CP patients, has shown effective results. Embryonic stem cells (ESC), mesenchymal stem cells (MSC), hematopoietic stem cells (HSC), human amnion epithelial cells (hAEC), and neural stem cells (NSC) are infused to reproduce into more specialized cell types. This alternative therapeutic method has shown successful results through preclinical animal research and clinical trials.

show abstract

Hemolytic-Uremic Syndrome

Cited by 9 publications

References 4 publications

Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

Association of Escherichia coli O157:H7 with necrotizing enterocolitis in a full-term infant

Epidemiología y Clínica del Síndrome Urémico Hemolítico (SUH). Análisis de tres períodos de observación

Untitled

Contact Info

Product

Resources

About