Hemolytic Uremic Syndrome in Leptospirosís bataviae

Hanvanich, M; Moollaor, Prachak; Suwangool, P; Sitprija, Visith

doi:10.1159/000183465

Cited by 9 publications

(5 citation statements)

References 4 publications

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“…Table I summarizes the lenalidomide-and thalidomide-based regimen and responses for all 24 patients. Nineteen of these patients tolerated and eventually progressed on lenalidomide having median treatment duration of 11.1 months, comparable with 11.3 months reported by the MM009 trial [2].…”

supporting

confidence: 78%

“…In the past, a small number of cases of leptospirosis have been reported to be associated with TTP [2][3][4]. We describe a further such case of leptospirosis, with presenting features suggestive of TTP and report, for the first time, an associated reduction in ADAMTS activity.…”

mentioning

confidence: 75%

“…Clinical studies have demonstrated that thalidomide and lenalidomide each have their own distinct toxicity and efficacy [1][2][3][4] despite sharing an overlapping immunomodulatory profile [5,6]. It is evident that patients previously refractory to the less potent IMiD thalidomide can still respond when treated with lenalidomide [7,8].…”

mentioning

confidence: 99%

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A case of leptospirosis presenting as TTP

Quinn

Conlon

et al. 2013

American J Hematol

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confidence: 78%

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confidence: 75%

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A case of leptospirosis presenting as TTP

Quinn

Conlon

et al. 2013

American J Hematol

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“…At the severe end of the disease spectrum, leptospirosis can present and mimic thrombotic microangiopathies [ 1 ]. HUS has been reported in Leptospira bataviae infection [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis presenting as haemolytic uraemic syndrome: a case report

2018

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BackgroundLeptospirosis is a rare infectious disease especially in Western Countries. Renal involvement is a recognised complication of leptospirosis but leptospirosis-associated haemolytic uraemic syndrome is extremely rare and to our knowledge has only been reported once, in 1985.Case presentationA 29-year-old male was transferred to our Renal Unit with fevers, myalgia and diarrhoeal illness. Laboratory investigations revealed an acute kidney injury, acute liver injury, significantly raised lactate dehydrogenase with marked anaemia, thrombocytopenia and schistocytes on a blood film. A diagnosis of haemolytic uraemic syndrome was made. Surprisingly, the stool culture was negative which led to a suspicion of leptospirosis as one of the differential diagnoses. This was subsequently confirmed by enzyme-linked immunosorbent assay and microscopic agglutination test. He received plasma exchange and antibiotics and made a complete recovery on discharge.ConclusionLeptospirosis presenting as haemolytic uraemic syndrome is rare but should be considered in the differential diagnosis especially in the presence of significant liver injury, as current evidence suggests that the disease is re-emerging.

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“…Impairment of renal functioning is one of the features of HUS and is a commonly found symptom in leptospirosis. Based on the findings of thrombocytopenia, fragmented red blood cells, reticulocytosis, high serum FDPs and renal failure the diagnosis of HUS in relation to leptospirosis was published as case report (Hanvanich et al. 1985).…”

Section: Haemorrhagic Syndromes In Leptospirosismentioning

confidence: 99%

What role do coagulation disorders play in the pathogenesis of leptospirosis?

Wagenaar

Goris

Adi

et al. 2006

Tropical Med Int Health

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SummaryLeptospirosis is a zoonosis of worldwide distribution, spread by the urine of infected animals. It is a major public health problem, especially in developing countries, where circumstances for transmission are most favourable. The clinical picture varies from mild disease to a severe illness with haemostatic derangements and multiorgan failure eventually leading to death. Although the haemorrhagic complications of severe disease are serious, the pathophysiology is scarcely elucidated. The complex mechanisms involved in inflammation-induced coagulation activation are extensively studied in various infectious diseases, i.e. Gram-negative sepsis. Tissue factor-mediated coagulation activation, impairment of anticoagulant and fibrinolytic pathways in close concert with the cytokine network are thought to be important. But for human leptospirosis, data are limited. Because of the growing interest in this field, the impact of leptospirosis, and the availability of new therapeutic strategies, we reviewed the evidence regarding the role of coagulation in leptospirosis and provide suggestions for future research.

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Hemolytic Uremic Syndrome in Leptospirosís bataviae

Cited by 9 publications

References 4 publications

A case of leptospirosis presenting as TTP

A case of leptospirosis presenting as TTP

Leptospirosis presenting as haemolytic uraemic syndrome: a case report

What role do coagulation disorders play in the pathogenesis of leptospirosis?

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