Leptospirosis presenting as haemolytic uraemic syndrome: a case report

Muthuppalaniappan, Vasantha Muthu; Rajakariar, Ravindra; Blunden, Mark

doi:10.1186/s12882-018-0817-5

Cited by 3 publications

(1 citation statement)

References 12 publications

(22 reference statements)

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“…Leptospirosis-induced kidney damages include interstitial nephritis, necrosis of renal tubular epithelial cells, and rupture of partial tubular basement membranes ( Yang, 2007 ; Yamaguchi et al., 2018 ). Therefore, in addition to the treatment against Leptospira and the approach to stabilize hemodynamics, the usage of glucocorticoid may also be beneficial for prognosis ( Muthuppalaniappan et al., 2018 ). Continuous hemodialysis can be one of the essential strategies for eliminating endotoxins, inflammatory mediators, and metabolic wastes, as well as regulating internal environment, managing blood volume, and nutrition support.…”

Section: Discussionmentioning

confidence: 99%

The diagnosis of leptospirosis complicated by pulmonary tuberculosis complemented by metagenomic next-generation sequencing: A case report

Shi

Wu²,

Kang³

et al. 2022

Front. Cell. Infect. Microbiol.

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Leptospirosis is a zoonotic infection caused by the pathogenic Leptospira. Leptospirosis is transmitted mainly through contact with contaminated rivers, lakes, or animals carrying Leptospira. Human leptospirosis has a wide range of non-specific clinical manifestations ranging from fever, hypotension, and myalgia to multi-organ dysfunction, which severely hampers the timely clinical diagnosis and treatment of leptospirosis. Therefore, there is an urgent clinical need for an efficient strategy/method that can be used for the accurate diagnosis of leptospirosis, especially in critically ill patients. Here, we report a case of a 75-year-old male patient with clinical presentation of fever, cough, and diarrhea. Initial laboratory tests and a computed tomography (CT) scan of the chest suggested only tuberculosis. The patient was finally diagnosed with pulmonary tuberculosis (PTB) combined with leptospirosis by sputum Xpert MTB RIF, epidemiological investigations, and delayed serological testing. Furthermore, through metagenomic next-generation sequencing (mNGS) of clinical samples of cerebrospinal fluid (CSF), urine, plasma and sputum, the causative pathogens were identified as Mycobacterium tuberculosis complex and Leptospira spp. With specific treatment for both leptospirosis and tuberculosis, and associated supportive care (e.g., hemodialysis), the patient showed a good prognosis. This case report suggests that mNGS can generate a useful complement to conventional pathogenic diagnostic methods through more detailed etiological screening (i.e., at the level of species or species complex).

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Section: Discussionmentioning

confidence: 99%