Hemolysis caused by pumps in extracorporeal circulation (in vitro evaluation of pumps)

Cahill, John J.; Kolff, Willem J.

doi:10.1152/jappl.1959.14.6.1039

Cited by 32 publications

(4 citation statements)

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“…Therefore, the hemocompatibility test of the VAD in the MCL is necessary. Numerous researchers chose MCLs with constant flow to perform the VAD hemocompatibility test, such as the hemolytic ( Cahill and Kolff, 1959 ; Takami et al, 1996 ; Rungsirikunnan et al, 2018 ) and thrombotic ( Linneweber et al, 2002 ; Linneweber et al, 2008 ; Maruyama et al, 2009 ; Dassanayaka et al, 2013 ; Zayat et al, 2019 ) investigations. For instance, a test loop was recommended by American Society of Testing Materials (ASTM) to conduct the in vitro hemolysis test on continuous VAD ( ASTM F1841-19, 2019 ).…”

Section: Applications Of MCL For Cadmentioning

confidence: 99%

Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies

Gao

Wan³

et al. 2023

Front. Physiol.

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The mock circulatory loop (MCL) is an in vitro experimental system that can provide continuous pulsatile flows and simulate different physiological or pathological parameters of the human circulation system. It is of great significance for testing cardiovascular assist device (CAD), which is a type of clinical instrument used to treat cardiovascular disease and alleviate the dilemma of insufficient donor hearts. The MCL installed with different types of CADs can simulate specific conditions of clinical surgery for evaluating the effectiveness and reliability of those CADs under the repeated performance tests and reliability tests. Also, patient-specific cardiovascular models can be employed in the circulation of MCL for targeted pathological study associated with hemodynamics. Therefore, The MCL system has various combinations of different functional units according to its richful applications, which are comprehensively reviewed in the current work. Four types of CADs including prosthetic heart valve (PHV), ventricular assist device (VAD), total artificial heart (TAH) and intra-aortic balloon pump (IABP) applied in MCL experiments are documented and compared in detail. Moreover, MCLs with more complicated structures for achieving advanced functions are further introduced, such as MCL for the pediatric application, MCL with anatomical phantoms and MCL synchronizing multiple circulation systems. By reviewing the constructions and functions of available MCLs, the features of MCLs for different applications are summarized, and directions of developing the MCLs are suggested.

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Section: Applications Of MCL For Cadmentioning

confidence: 99%

Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies

Gao

Wan³

et al. 2023

Front. Physiol.

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“…It is a well-known fact that pump perfusion can inflict continuous damage on the blood cells (e.g. Cahill & Kolff 1959, Bernstein, Castaneda & Varco 1965, Bernstein & Gleason 1967. The immediate effect of a breakdown of red blood cells, measured as hemolysis, is usually taken as a measure of such cell damage and was adopted here.…”

Section: Q=3%mentioning

confidence: 99%

A servo‐controlled roller pump for constant flow or constant pressure blood perfusion under normal pulsatile or non‐pulsatile conditions

Borgström

Clementz

Grände

1981

Acta Physiologica Scandinavica

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This paper describes the design of a servo-controlled precision roller pump applicable for constant blood flow or constant blood pressure perfusion in research on the peripheral circulation. The pump, and its feed-back control, can simulate normal cardiac induced autoperfusion by reproducing the arterial pulse pressure configuration with high fidelity. Its design is such as to minimize damage of the red blood cells and consequent release of vasoactive substances, a problem encountered with most conventional pumps. The present pump principle may also find a use in heart-lung machines and dialysis equipment and can be used as a precision infusion pump.

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“…Care is needed to maintain the same flow pattern and oxygen concentration, and not to damage the blood cells, so that most of the development has been directed at improving these features. 132 However, most heart-lung machines at present are designed to give a nonpulsatile flow, to avoid damage to red blood cells (haemolysis).…”

Section: Heart-lung Machinementioning

confidence: 99%

Biomedical engineering

Perkins¹

1971

Proc. Inst. Electr. Eng. UK

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The increasing sophistication of modern technology and its widening areas of application have established the need for multidisciplinary activities, and biomedical engineering is a typical example of this trend. The evolution of the subject from the engineering approach of earlier biomedical workers is described, and some of the lessons learned before and during the transition are considered. An approach to this now rather extensive subject is made by separating the application to biomedical research from that to clinical medicine, The research section is stratified according to the level of biological organisation with which it is concerned, that is, from the molecular systems of biochemistry to the organ systems of physiology. At each level, sufficient background is given to show the relevance of biomedical engineering, and this approach is continued with the clinical applications, which are considered within conventional medical categories. The principal contribution to medicine is found to lie with the innovation of the new methods made possible by advancing technology. The more recent technological ideas of organ and function replacement are discussed followed by that of computer usage in various areas of biomedicine. In conclusion, a critical assessment of present achievements is attempted, and the possible future of biomedical engineering is discussed.

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Hemolysis caused by pumps in extracorporeal circulation (in vitro evaluation of pumps)

Cited by 32 publications

References 0 publications

Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies

Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies

A servo‐controlled roller pump for constant flow or constant pressure blood perfusion under normal pulsatile or non‐pulsatile conditions

Biomedical engineering

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