Hemoglobin‐Related Biomaterials and their Applications

Li, Shaobing; Sun, Wei; Ouyang, Minggao; Yu, Bo; Chen, Yan; Wang, Yupeng; Zhou, Dongfang

doi:10.1002/anbr.202200103

Cited by 3 publications

(1 citation statement)

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“…Strategies such as carrying oxygen into tumor tissues via oxygen carriers such as hemoglobin (Hb) and perfluorocarbon and generating oxygen in situ by decomposing endogenous H 2 O 2 have been developed to relieve hypoxia in the TME. [13][14][15][16] However, most of the strategies mentioned above are only in preclinical studies and require more comprehensive investigations to realize practical clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen‐Facilitated Cancer Treatment: A Minireview

Li,

Zhang,

2024

Advanced NanoBiomed Research

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Hypoxia in malignant tumors is a major factor in inducing the failure of clinical cancer treatment. Although several strategies have been developed to relieve hypoxia, most are still in the preclinical research phase. Therefore, hyperbaric oxygen (HBO), an approved adjuvant therapy for alleviating hypoxia clinically, is an excellent choice for enhancing the efficacy of cancer treatment that is impeded by tumor hypoxia. In this minireview, recent advances in HBO‐facilitated cancer treatment, including clinical applications and nanomedicine‐mediated cancer therapy are introduced. At the end of this minireview, the potential challenges faced by HBO therapy before clinical use are discussed. It is hoped that this review will provide a reference for future clinical research on the application of HBO in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen‐Facilitated Cancer Treatment: A Minireview

Li,

Zhang,

2024

Advanced NanoBiomed Research

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Engineering Sonosensitizer‐Derived Nanotheranostics for Augmented Sonodynamic Therapy

Yang,

Lv,

et al. 2024

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Sonodynamic therapy (SDT), featuring noninvasive, deeper penetration, low cost, and repeatability, is a promising therapy approach for deep‐seated tumors. However, the general or only utilization of SDT shows low efficiency and unsatisfactory treatment outcomes due to the complicated tumor microenvironment (TME) and SDT process. To circumvent the issues, three feasible approaches for enhancing SDT‐based therapeutic effects, including sonosensitizer optimization, strategies for conquering hypoxia TME, and combinational therapy are summarized, with a particular focus on the combination therapy of SDT with other therapy modalities, including chemodynamic therapy, photodynamic therapy, photothermal therapy, chemotherapy, starvation therapy, gas therapy, and immunotherapy. In the end, the current challenges in SDT‐based therapy on tumors are discussed and feasible approaches for enhanced therapeutic effects are provided. It is envisioned that this review will provide new insight into the strategic design of high‐efficiency sonosensitizer‐derived nanotheranostics, thereby augmenting SDT and accelerating the potential clinical transformation.

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