Hemoglobin Kansas found by electrophoretic diagnosis in Brazil

Abstract

Some hemoglobin variants with abnormal oxygen affinity have been reported so far from various regions of the world. They can be classified by their oxygen affinity and 15 variants with low oxygen affinity have been reported. A number of hemoglobin mutants which show an abnormal affinity for oxygen have been reported, but only few cases of hemoglobin Kansas. All cases reported so far are from Japan or in Japanese families. In this paper we describe a Brazilian patient with cyanosis and hemoglobin Kansas diagnosed by an electrophoretical procedure.

The Second and Third Hemoglobin Kansas Cases in the Turkish Population

“…Therefore, tissues get oxygenated even at low hematocrit levels and patients appear to be healthy. However, cyanosis is seen because the unsaturated hemoglobin amount in the capillaries and veins is higher than 5 g/dL [ 4 ]. The P50 values of these patients are also high [ 5 , 6 ].…”

“…In total, six hemoglobin Kansas cases were reported from 1968 to date in the world literature [ 2 , 3 , 4 , 5 ]. The first hemoglobin Kansas case in Turkey was reported in 2015 [ 1 ].…”

Hemoglobinas anormais em sangue de cordão umbilical

“…Pretos e pardos constituem 45% de toda a população e cerca de 99% da população "não branca". 1,2 Curiosamente, na Pesquisa Nacional por Amostra de Domicílios, 2 apenas 5,4% dos brasileiros declaram a sua cor como preta.…”

“…mentando os programas de controle destas alterações e o aconselhamento genético. 1,2 Doença falciforme é o termo genérico para a família das hemoglobinopatias caracterizadas pela presença da hemoglobina S (Hb S). O defeito genético constitui basicamente a substituição do ácido glutâmico pela valina na posição seis da cadeia beta da hemoglobina.…”