Hemoglobin F as a predictor of health-related quality of life in children with sickle cell anemia

Boulassel, Mohamed-Rachid; Al-Badi, Amira; Elshinawy, Mohamed; Al-Hinai, Juhaina; Saadoon, Muna Al; Al-Qarni, Zahra; Khan, Hammad; Qureshi, Rizwan; Wali, Yasser

doi:10.1007/s11136-018-2031-0

Cited by 10 publications

(18 citation statements)

References 36 publications

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“…However, the pain impact, pain crisis, pain management and control that the haemoglobin F out-weighed white blood cell count which is an important predictor of poor HRQOL in Omani children with SCA [33]. Similar to the study results of Boulassel et al [33], our study also highlighted that Omani children had poor HRQOL scores in terms of emotional and psychological domains.…”

Section: Discussionsupporting

confidence: 87%

“…erefore, this study highlighted that pain is one of the important predictor for poor HRQOL score in terms of physical, psychological and social functioning which is supported by similar nding of other studies [27][28][29][30]. However, the pain impact, pain crisis, pain management and control that the haemoglobin F out-weighed white blood cell count which is an important predictor of poor HRQOL in Omani children with SCA [33]. Similar to the study results of Boulassel et al [33], our study also highlighted that Omani children had poor HRQOL scores in terms of emotional and psychological domains.…”

Section: Discussionsupporting

confidence: 81%

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Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study

Pandarakutty

Murali

Arulappan

et al. 2019

Advances in Hematology

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Introduction. The children with Sickle Cell Disease (SCD) generally have poor Health Related Quality of Life (HRQOL). The study aimed to evaluate the effectiveness of nurse led intervention on HRQOL among children with SCD. Methods. A total of 30 samples were selected using convenient sampling. Children with SCD and their caregivers completed Pediatric Quality of Life Inventory (PedsQL) SCD-Module version 3.0. The nurse led intervention was given to the study group for 10 consecutive weeks. The control group received the routine medical care. On completion of 10 weeks, the post-test was conducted. Results. The participants in study group had poor HRQOL scores P>0.05 in pre-test. After nurse led intervention, the HRQOL score in the study group significantly improved P<0.05. The control group did not show any significant difference in the pretest and post-test. Discussion. Therefore nurse led intervention is effective in improving HRQOL among children with SCD.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 81%

Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study

Pandarakutty

Murali

Arulappan

et al. 2019

Advances in Hematology

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“…A total of 10 articles were included in the systematic review [Table 1]. 21,[43][44][45][46][47][48][49][50][51] Of these, nine were observational studies, including five cross-sectional, two case-control and two cohort studies. 21,[44][45][46][47][48][49][50][51] The *Methodological quality was assessed using an adapted version of the Newcastle-Ottawa Quality Assessment Scale, except for mixed-method studies, which were assessed using the Mixed Methods Appraisal Tool.…”

Section: S T U D Y C H a R A C T E R I S T I C Smentioning

confidence: 99%

“…21,[43][44][45][46][47][48][49][50][51] Of these, nine were observational studies, including five cross-sectional, two case-control and two cohort studies. 21,[44][45][46][47][48][49][50][51] The *Methodological quality was assessed using an adapted version of the Newcastle-Ottawa Quality Assessment Scale, except for mixed-method studies, which were assessed using the Mixed Methods Appraisal Tool. 41,42 Cross-sectional, cohort and case-control studies were scored out of 8, 6 and 9, respectively, with scores of <50% considered to indicate poor methodological quality.…”

Section: S T U D Y C H a R A C T E R I S T I C Smentioning

confidence: 99%

“…Four studies were conducted in Saudi Arabia, two in Turkey and one each in Iraq, Sudan, Uganda and Oman. 21,[43][44][45][46][47][48][49][50][51] Most of the studies focused primarily on children and adolescents aged 2-18 years. 21,[43][44][45][46]48,50,51 However, two studies focused both on paediatric and young adult populations aged 18-22 years.…”

Section: S T U D Y C H a R A C T E R I S T I C Smentioning

confidence: 99%

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Health-Related Quality of Life of Children and Adolescents with Sickle Cell Disease in the Middle East and North Africa Region

Pandarakutty

Murali

Arulappan

et al. 2020

Sultan Qaboos Univ Med J

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Sickle cell disease (SCD) can significantly impair the health-related quality of life (HRQOL) of children and adolescents. This review aimed to assess current evidence regarding the HRQOL of children and adolescents with SCD in the Middle East and North Africa region. A systematic search of various databases was conducted to identify relevant articles, including MEDLINE® (National Library of Medicine, Bethesda, Maryland, USA), Scopus® (Elsevier, Amsterdam, the Netherlands), Cumulative Index to Nursing and Allied Health Literature®, Masader (Oman Virtual Science Library, Muscat, Oman) and EBSCOhost (EBSCO Information Services, Ipswich, Massachusetts, USA). A total of 533 articles were identified; however, only 10 were eligible for inclusion in the final analysis. Results from these studies showed that children and adolescents with SCD had compromised HRQOL compared to their healthy peers, particularly in terms of physical, psychosocial, familial, financial and academic functioning. Therefore, interventions are necessary to improve overall HRQOL outcomes for this population. Keywords: Sickle Cell Disease; Health-Related Quality Of Life; Infants; Children; Adolescents; Middle East; North Africa.

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Health‐related quality of life of patients with sickle cell disease aged 8–17 years at Kamuzu Central Hospital, Malawi

Wachepa

Bvalani

Namubiru

et al. 2022

Pediatric Blood & Cancer

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Background: Sickle cell disease (SCD) is characterized by both acute and chronic complications that affect the daily lives of patients and lower their quality of life.Objective: To describe the health-related quality of life (HRQoL) and the associated factors in children aged 8-17 years with SCD attending the pediatric hematology clinic at Kamuzu Central Hospital (KCH) in Lilongwe, Malawi. Methods:A mixed-methods cross-sectional study was conducted at KCH. Patient data were collected with the aid of a standardized case report form. HRQoL was assessed using PedsQL™ Sickle Cell Disease Module by the child's report. Associations between HRQoL scores and independent variables were evaluated by a linear regression model.In-depth interviews were then carried out and the qualitative data were analyzed using content thematic analysis. Results:A hundred and sixty-three children with SCD were enrolled and 52.1% were females. Their median age was 11.2 ± 2.7 years. The mean global HRQoL score of the children was 62 ± 17.3. The highest scores were in the treatment domain (72.5 ± 15.1) while the lowest scores were in the emotions domain (55.2 ± 28.7). The mean pain score was 58.8 ± 16.3. The factors associated with low HRQoL scores were pain (β-coefficient −6.97 CI (−3.07,−15.58); p value .034) and low hemoglobin levels (β-coefficient 2.29 CI (.65-3.91); p value .006). Conclusion:The HRQoL of this population is low. Pain and low hemoglobin were significantly associated with low HRQoL scores. Adequate treatment to control pain and increase the steady-state hemoglobin may improve the HRQoL of children with SCD.

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Hemoglobin F as a predictor of health-related quality of life in children with sickle cell anemia

Cited by 10 publications

References 36 publications

Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study

Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study

Health-Related Quality of Life of Children and Adolescents with Sickle Cell Disease in the Middle East and North Africa Region

Health‐related quality of life of patients with sickle cell disease aged 8–17 years at Kamuzu Central Hospital, Malawi

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