Hemoglobin AE, AO-Arab and SO-Arab Genotypes in Burkina Faso: Hematological Parameters, Genotypic and Allelic Frequencies of Hemoglobinopathies

Traoré, M.; Zohoncon, Théodora Mahoukèdè; Ouédraogo, Paul; Ouattara, Abdoul Karim; Obiri‐Yeboah, Dorcas; Tao, Issoufou; Ganane, Geoffroy; Belemgnegre, Marius; Boro, Theodore; Sanou, Fabienne; Simporé, Jacques

doi:10.29245/2690-0009/2020/1.1109

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…While the HbSS and HbSC diseases are highly prevalent in areas of Sub-Saharan Africa, particularly West Africa, the HbSβ-Thal, HbSD and HbSE are more common in parts of the Middle East and Asia. [5][6][7][8][9][10] The prevalence of the carrier state for HbS ranges from 5% to 40% among populations in these endemic areas; thus driving the epidemiology of the disease. [10,11] Sickle cell disease (SCD), has major psychological, social and economic implication on the victim as well as the family.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria

Yalma¹,

Awodiji²

2021

EJPM

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The knowledge, attitude and practice of genotype screening for sickle cell are very important in the control and prevention of sickle cell disease (SCD). The objectives of this study therefore are to determine the knowledge, attitude and practice of genotype screening among undergraduate students of the University of Abuja, Nigeria. The study was a descriptive cross-sectional study. A sample size of 256 was studied and multi-stage sampling technique was used to select the faculties, departments and participants. Data was collected by using self-administered, semi-structured questionnaire. Associations between variables and proportions were ascertained using Chi-square tests at 5% level of statistical significance. Most of the respondents were males (51.1%) and majority belong to age group of 21-25 years. About 98% of the students have good knowledge of genotype screening for sickle cell. Also, 93.8% of the students had positive attitude to genotype screening and 76.6% of the participants had ever had a genotype screening with 52.7% having AA genotype, 18.4% AS and 5.5% with SS genotype. In addition, the study revealed a statistically significant association between good knowledge of genotype screening and the practice (98.0% vs. 58.2%; p value <0.003). Since the students have good knowledge and positive attitude to genotype screening, increased awareness on genotype screening should be encouraged so as to increase the uptake of screening and reduce the burden of sickle cell disease.

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Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria

Yalma¹,

Awodiji²

2021

EJPM

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The Inequality of Pain Control in Patients With Pain From Sickle Cell Disease: A Case Report

Cofield,

Tyner

2024

Journal of Pediatric Health Care

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Incidence of Sickle Cell Disease and Other Hemoglobinopathies in Burkina Faso: Results of a Five-Year Systematic Neonatal Screening (2015-2019) in Four Urban Hospitals

SAWADOGO¹,

Nébié²,

Kima³

et al. 2022

OJBD

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Hemoglobinopathies, mainly Sickle cell disease (SCD), are the most common monogenic disorders in Africa. In Burkina Faso, data on these diseases are scarce, mainly hospital-based in Ouagadougou and its surroundings. In order to assess the incidence and allelic frequencies of the main hemoglobinopathies in newborns in Burkina Faso, we conducted a cross-sectional study from 2015 to 2019 in four hospitals. The study included babies of both sexes, regardless of ethnic group and parents' hemoglobin status. It was a newborn screening and hemoglobin variants were detected using isoelectric focusing on cord blood samples and confirmed using hemoglobin electrophoresis by high-performance liquid chromatography. The proportions and cumulative incidences of the different hemoglobinopathies were computed. Hardy-Weinberg equilibrium law was applied to calculate genotypic and allelic frequencies. The significant level was p < 0.05. Out of 11,337 newborns included, 47.8% were males and 60.2% were from Bobo-Dioulasso. Abnormal hemoglobin was found in 27.1%, representing a cumulative incidence of 1:4 newborns. The incidence of SCD was 1.9% (1:53 newborns) with 27.9% of homozygous SS. Homozygous CC and compound heterozygous Cβ-Thalassemia accounted for 1.1%.

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Hemoglobin AE, AO-Arab and SO-Arab Genotypes in Burkina Faso: Hematological Parameters, Genotypic and Allelic Frequencies of Hemoglobinopathies

Cited by 3 publications

References 15 publications

Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria

Knowledge, Attitude and Practice of Genotype Screening Among Undergraduate Students of the University of Abuja, Nigeria

The Inequality of Pain Control in Patients With Pain From Sickle Cell Disease: A Case Report

Incidence of Sickle Cell Disease and Other Hemoglobinopathies in Burkina Faso: Results of a Five-Year Systematic Neonatal Screening (2015-2019) in Four Urban Hospitals

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