Hemodynamic Responses to Exercise in Clinically Normal Middle-aged Men and in Those with Angina Pectoris *

Foster, Glenn L.; Reeves, Tim; Meade, James H.

doi:10.1172/jci105050

Cited by 37 publications

(8 citation statements)

References 15 publications

(13 reference statements)

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“…In 2 patients, it was just within the lower limit of the normal range; i. e. when exercise had to be discontinued because of angina, the patients were in left heart failure. This finding confirms the results of other authors (7,14,20,21,23). Probably acute left heart failure is the most important factor to limit exercise tolerance of patients with angina pectoris.…”

Section: Pump Functionsupporting

confidence: 92%

The ischemic segment and left ventricular function during exercise angina

Rentrop

Karsch

Nitsche

1978

Clinical Cardiology

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Summary: Improvement of the quality of transpulmonary left ventriculograms by exercise was demonstrated in 5 patients in a pre-study. In the main study transpulmonary left ventriculography was performed in 10 patients with coronary artery disease (CAD) at rest and during exercise, producing maximum angina pectoris (AP). Left ventricular pressure was recorded simultaneously. The extent of CAD, demonstrated in all patients by coronary angiography, was quantitated by a score. In the exercise ventriculograms, local wall motion was quantitated by 14 hemiaxes. During exercise AP, all patients developed wall motion abnormalities not present at rest. There was a significant linear correlation between coronary score and number of abmormally shortening hemiaxes « 30% shortening) during exercise-AP (y = 0.16 x + 4.34; r = 0.933). The number of anormal hemiaxes correlated significantly (p < 0.05) with left ventricular enddiastolic pressure (LVEDP), dp/dt min, endsystolic volume index, enddiastolic volume index, ejection fraction, stroke work index, minute work, compliance SV / L1 PD/ESV, and cardiac index. During exercise AP the extent of ischemic wall motion abnormalities is determined by localization and severity of coronary artery lesions. The extent of ischemic impairment of wall motion determines the severity of impairment of left ventricular pump function, filling pressure, and maximum speed of relaxation. Transpulmonary left ventriculography during exercise AP is a safe and relatively simple method to quantitate the extent of ischemic wall motion abnormalities. It could be useful in the selection of patients for coronary artery surgery and in the assessment of the results of this operation.lbc sludies were performed in the catheterization laboratories of the Georg-August-University Gocttingen and the Rehabilitationszentrum Bad Krozingcn, West Germany.

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Section: Pump Functionsupporting

confidence: 92%

The ischemic segment and left ventricular function during exercise angina

Rentrop

Karsch

Nitsche

1978

Clinical Cardiology

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“…Comparable observations in 2 patients are reported by Muller and R0rvik (1958). Reports of a less-thannormal increase in mean systolic ejection rate (Foster and Reeves, 1964;Messer et al, 1963;Cohen et al, 1965) may have been due to differences in case material. From our data it seems that the exercise response with respect to the parameters measured may be within normal limits in such subjects when they are experiencing anginal pain.…”

Section: Discussionmentioning

confidence: 98%

Haemodynamic effects of angina pectoris, and of nitroglycerin in normal and anginal subjects.

Hoeschen¹,

Bousvaros²,

Klassen³

et al. 1966

Heart

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“…Abnormalities ofventricular contraction have been reported in ischlmic heart disease (Messer et al, 1963), and there is evidence that the cardiac output is reduced on exercise in these patients (Foster and Reeves, 1964). Beta-adrenergic blockade has been shown to reduce myocardial contractility (Harrison et al, 1964), and might be expected to accentuate these changes.…”

Section: Discussionmentioning

confidence: 99%