Hemodynamic profile in severe ARDS: results of the European Collaborative ARDS Study

Abstract

In addition to the cause of ARDS and the early time-course of lung function, a high systolic PAP and a low diastolic SAP were strong independent indicators of survival.

Incidence and short-term outcome of acute lung injury in mechanically ventilated children

“…This suggests that the initial trigger negatively influences further organ dysfunction and final outcome. One paediatric study on AHRF and multiple adult studies showed that underlying diseases, such as cerebral dysfunction and immune disorders, have a greater impact on outcome than respiratory failure alone [7,18,[22][23][24][25][26][27][28]. These findings suggest that ALI may be more a symptom than a limiting disease.…”

The Physiology of Ventilation

“…38 Traditionally, pulmonary hypertension in the course of ARDS was considered a predictor of poor outcome. 67 However, in the era of lung-protective ventilation using low V T , elevated systolic pulmonary artery pressure early in the course of ARDS is not necessarily predictive of poor outcome, although a persistently large dead space in early ARDS remains associated with increased mortality and fewer ventilator-free days. 68 Several studies have demonstrated this association.…”

Update on the Role of Extracorporeal CO2 Removal as an Adjunct to Mechanical Ventilation in ARDS

“…Mortality rates for ARDS have decreased over time but still remain around 40%, in large part a result of the hemodynamic complications of this syndrome [3]. ARDS has various etiologies and early diagnosis and intervention are key to improving outcomes [4].…”