Hemodynamic effects of peptide fragments of differentiation factor HLDF

We studied the relationships between the blood serum levels of human leukemia differentiation factor HLDF, idiotypic and anti-idiotypic antibodies to HLDF, and clinical indicators of cardiovascular function in apparently healthy individuals and patients with essential hypertension and cerebral hypertensive crisis. Markedly reduced HLDF levels and anti-HLDF antibody titers were found in the blood of the examined patients. Correlations between HLDF levels, duration of hypertension, and systolic and diastolic BP were revealed. These findings suggest that the studied molecular factors are involved in the mechanisms of BP regulation under normal conditions and during hypertension development. The protein HLDF and anti-HLDF antibodies can be considered as biomarkers for early diagnosis of hypertension and its cerebral complications.

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Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis

Elistratova

Gruden

Шерстнев

2012

Bull Exp Biol Med

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Content of S100b Protein, HLDF24 Peptide and Autoantibodies to These Factors as Potential Biomarkers for Arterial Hypertension in Blood Serum of Healthy People

et al. 2014

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The content of S100b protein, HLDF24 peptide, and autoantibodies to these factors in blood serum was measured in healthy individuals (35-64-year-old men and women) with various levels of "normal" BP. Significant differences in the amount of these molecular factors were found in individuals with various categories of BP. We revealed age-related and gender differences in the content of molecular factors in the serum. Our results indicate that variations in the concentration of S100b, HLDF24, and autoantibodies to these factors in blood serum from adult people can serve as a reliable criterion for the risk of arterial hypertension.

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Serum Level of HLDF24 Peptide as an Objective Marker of Prehypertension

et al. 2020

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Hemodynamic effects of peptide fragments of differentiation factor HLDF

Cited by 3 publications

References 9 publications

Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis

Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis

Content of S100b Protein, HLDF24 Peptide and Autoantibodies to These Factors as Potential Biomarkers for Arterial Hypertension in Blood Serum of Healthy People

Serum Level of HLDF24 Peptide as an Objective Marker of Prehypertension

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