Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis

Elistratova, E. I.; Gruden, M. A.; Шерстнев, В. В.

doi:10.1007/s10517-012-1793-6

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…TRIM52 encodes TRIM52 protein that positively regulates the nuclear factor-kappa B signaling pathway [13]. RPS21 (also known as HLDF) encodes HLDF protein that is involved in the mechanisms of blood pressure regulation [14]. AMOTL2 is required for migration and proliferation of endothelial cells during angiogenesis [15].…”

Section: Discussionmentioning

confidence: 99%

Expression Profiles of Long Noncoding RNA and mRNA in Epicardial Adipose Tissue in Patients with Heart Failure

Zheng

Zhao

Yang

2019

BioMed Research International

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The expression profile of long noncoding RNA (lncRNA) in human epicardial adipose tissue (EAT) has not been widely studied. In the present study, we performed RNA sequencing to analyze the expression profiles of lncRNA and mRNA in EAT in coronary artery disease (CAD) patients with and without heart failure (HF). Our results showed RNA sequencing disclosed 35673 mRNA and 11087 lncRNA corresponding to 15554 genes in EAT in total, while 30 differentially expressed lncRNAs (17 upregulated and 13 downregulated) and 278 differentially expressed mRNAs (129 upregulated and 149 downregulated) were discriminated between CAD patients with and without HF (P<0.05; fold change>2); lncRNA ENST00000610659 drew specific attention for it was the top upregulated lncRNA with highest fold change and corresponded to UNC93B1 gene, which was proved to be related to HF and encoded UNC93B1 protein regulating toll-like receptor signaling, and both of them significantly increased in HF patients in qRT-PCR validation; the top significant upregulated enriched GO terms and KEGG pathway analysis were regulation of lymphocyte activation (GO:0051249) and T cell receptor signaling pathway (hsa04660), respectively. The current findings support the fact that EAT lncRNAs are involved in the inflammatory response leading to the development of HF.

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Section: Discussionmentioning

confidence: 99%

Expression Profiles of Long Noncoding RNA and mRNA in Epicardial Adipose Tissue in Patients with Heart Failure

Zheng

Zhao

Yang

2019

BioMed Research International

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Content of S100b Protein, HLDF24 Peptide and Autoantibodies to These Factors as Potential Biomarkers for Arterial Hypertension in Blood Serum of Healthy People

et al. 2014

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The content of S100b protein, HLDF24 peptide, and autoantibodies to these factors in blood serum was measured in healthy individuals (35-64-year-old men and women) with various levels of "normal" BP. Significant differences in the amount of these molecular factors were found in individuals with various categories of BP. We revealed age-related and gender differences in the content of molecular factors in the serum. Our results indicate that variations in the concentration of S100b, HLDF24, and autoantibodies to these factors in blood serum from adult people can serve as a reliable criterion for the risk of arterial hypertension.

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Molecular Markers of Arterial Hypertension in Patients with Normotony, Pre-Hypertension and Hypertension

Шерстнев¹,

Gruden²,

Elistratova³

et al. 2015

Bull Exp Biol Med

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We studied concentrations of angiotensin II, HLDF24 peptide, endothelin proteins, S100B, and autoantibodies to them and serum levels of blood natriuretic peptide in patients with different categories of "normal" arterial BP and hypertension. The relationship between blood levels of the above factors and normotony, pre-hypertension, and hypertension in the examined groups was analyzed. The results suggest that the studied molecular factors can serve as potential predictors of arterial hypertension and used for personalized hypertension risk assessment.

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Involvement of HLDF Protein and Anti-HLDF Antibodies in the Mechanisms of Blood Pressure Regulation in Healthy Individuals and Patients with Stable Hypertension and Hypertensive Crisis

Cited by 3 publications

References 8 publications

Expression Profiles of Long Noncoding RNA and mRNA in Epicardial Adipose Tissue in Patients with Heart Failure

Expression Profiles of Long Noncoding RNA and mRNA in Epicardial Adipose Tissue in Patients with Heart Failure

Content of S100b Protein, HLDF24 Peptide and Autoantibodies to These Factors as Potential Biomarkers for Arterial Hypertension in Blood Serum of Healthy People

Molecular Markers of Arterial Hypertension in Patients with Normotony, Pre-Hypertension and Hypertension

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