Hemodynamic Effect of Iodinated High-Viscosity Contrast Medium in the Rat Kidney

Laissy, Jean-Pierre; Menegazzo, David; Dumont, Erik; Piekarski, J.D.; Karila-Cohen, P.; Chillon, Sylvie; Schouman-Claeys, É.

doi:10.1097/00004424-200011000-00001

Cited by 26 publications

(27 citation statements)

References 28 publications

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“…Our results are partially supported by a previous report by Laissy et al (19). In their study, a dynamic serial DW-MRI was performed to monitor the effects of isosmotic iodixanol on the renal function based on a rat model.…”

Section: Discussionsupporting

confidence: 89%

Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion‐weighted MRI

Wang

Zhang

Yang

et al. 2012

Magnetic Resonance Imaging

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Purpose: To assess the effects of intravenous-injected iodinated contrast medium (CM) on intrarenal water diffusion using noninvasive diffusion-weighted MRI (DW-MRI). Materials and Methods:Ten New Zealand White rabbits were randomized to receive a 6 mL/kg body weight intravenous injection of clinically used iopamidol-370 (n ¼ 7) or an equivalent amount of 0.9% physiological saline (n ¼ 3). A sequential DW-MRI was performed to estimate the intrarenal apparent diffusion coefficient (ADC) at 24 h before and 1 h, 24 h, 48 h, and 72 h after administration.Results: Iopamidol produced a progressive ADC reduction in inner stripes of the renal outer medulla (IS) by 13.92% (P ¼ 0.05) at 1 h, 17.52% (P ¼ 0.02) at 24 h, 20.23% (P ¼ 0.01) at 48 h and 16.31% (P ¼ 0.04) at 72 h after injection. Cortical ADC was decreased by 14.14% (P ¼ 0.01) at 48 h and 14.12% (P ¼ 0.01) at 72 h after injection. Iopamidol produced slight decrease of ADCs in outer stripes of the outer medulla (OS) and inner medulla (IM) of kidney but without statistical difference. In control group, no significant ADC changes was observed in each anatomic compartment due to saline injection (P > 0.05). Conclusion:As demonstrated by DW-MRI, intravenous iopamidol injection resulted in a successive reduction of intrarenal water diffusion, particularly in IS of kidney. This MR technique may be used as a noninvasive tool to perform a time course study of the pathogenesis associated with contrast-induced nephropathy (CIN).

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Section: Discussionsupporting

confidence: 89%

Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion‐weighted MRI

Wang

Zhang

Yang

et al. 2012

Magnetic Resonance Imaging

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“…However, our data provide values which are in the mid-range of those reported to date, and the lower standard deviations of our results provide further confidence in our findings. Some authors [8,13,16] have reported higher values in the medulla as compared with the renal cortex, and this finding was validated by the results obtained by Laissy et al in rats [14]. We did not try to evaluate ADC values in the cortex and in the medulla separately because it may be difficult and inaccurate to position the ROI cursor on the renal cortex and medulla of the kidney separately, as already pointed out by Fukuda et al [9].…”

Section: Discussionsupporting

confidence: 73%

“…The kidney is well suited for diffusion studies because of its high blood flow and its fluid transport function. According to some authors [13,14], these factors can explain the higher renal ADC values as compared with other organs.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted MRI in the evaluation of renal lesions: preliminary results

Cova

Squillaci²,

Stacul³

et al. 2004

BJR

203

147

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Abstract. The purpose of this study was to evaluate the capability and the reliability of diffusion-weighted MRI in the evaluation of normal kidney and different renal lesions. 39 patients (10 normal volunteers and 29 patients with known renal lesions) underwent MRI of the kidneys by using a 1.5 T superconducting magnet. Axial fat suppressed turbo spin echo (TSE) T 2 and coronal fast field echo (FFE) T 1 or TSE T 1 weighted images were acquired for each patient. Diffusion-weighted (DW) images were obtained in the axial plane during breath-hold (17 s) with a spin-echo echo planar imaging (SE EPI) single shot sequence (repetition time (TR)52883 ms, echo time (TE)561 ms, flip angle590˚), with b value of 500 s mm 22 . 16 slices were produced with slice thickness of 7 mm and interslice gap of 1 mm. An apparent diffusion coefficient (ADC) map was obtained at each slice position. The ADC was measured in an approximately 1 cm region of interest (ROI) within the normal renal parenchyma, the detected renal lesions and the collecting system if dilated. ADC values in normal renal parenchyma ranged from 1. In conclusion diffusion-weighted MR imaging of the kidney seems to be a reliable way to differentiate normal renal parenchyma and different renal diseases. Clinical experience with this method is still preliminary and further studies are required.MR diffusion-weighted imaging (DWI) is widely used in neuroimaging, particularly for the evaluation of acute cerebral stroke, intracranial tumours and demyelinating diseases [1][2][3][4][5][6]. Application of MR DWI outside the central nervous system has been limited by its inherent extreme sensitivity to motion. In the abdomen the use of DWI has been hampered by the presence of spontaneous motion such as respiration, peristalsis and blood flow, which are orders of magnitude greater than diffusional motion and can easily obscure the effect of diffusion. However, recent advances in ultrafast MRI methodologies make it possible to overcome many motion-related problems and to obtain reliable DW images of the abdominal organs [7]. DWI holds great potential for abdominal imaging, in particular for focal lesion detection and characterization, and the evaluation of diffuse parenchymal diseases for which current techniques are often inadequate. Recent studies have already shown the potential value of this method in the evaluation of various renal diseases, such as renal infection, renal ischaemia, pyonephrosis and diffuse renal disease [8][9][10][11][12].The purpose of our study was to evaluate the capability and reliability of MR DWI in the evaluation of normal kidney and of different renal lesions. Materials and methods10 subjects (6 men, 4 women; age range 30-72 years; mean age 50 years) with normal kidneys and 29 patients (16 men, 13 women; age range 45-85 years; mean age 62 years) with known renal lesions previously diagnosed by ultrasound and/or CT, as simple cysts 13 cases; hydronephrosis 6 cases; pyonephrosis 3 cases; solid tumours 7 cases (3 histologically proven renal cell carcin...

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“…Until recently, only a few studies have involved measurement of water diffusion in the kidneys [11][12][13][14][15]. Some investigators have reported higher values in the medulla than in the cortex of the kidney [11,15], whereas others have reported the opposite [13,14].…”

Section: Discussionmentioning

confidence: 99%

Role of diffusion-weighted MRI in diagnosis of acute renal allograft dysfunction: a prospective preliminary study

El-Ghar

El-Diasty²,

El‐Assmy³

et al. 2012

BJR

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Objective: The aim was to evaluate the effects of diagnostic performance of diffusionweighted (DW) MRI in the assessment of acute impairment of transplanted kidneys. Methods: From January 2009 to January 2010, 49 patients with stable renal allograft function (Group 1) and 21 patients with acute graft impairment (Group 2) were included in the study. All patients were evaluated with coronal T 2 weighted (T 2 W) and DW MRI of the kidney. Patients in Group 2 underwent graft biopsy to determine the underlying histopathological aetiology. Apparent diffusion coefficient (ADC) was calculated and the kidneys were studied for any areas of diffusion restriction. Two radiologists, who were blinded to the results of histopathology, independently interpreted the T 2 W and DW images. Results: The histopathological diagnosis ofGroup 2 (21 patients) was acute cellular rejection (ACR) in 10, acute tubular necrosis (ATN) in 7 and immunosuppressive toxicity in 4 patients. ADC values in Group 1 were significantly higher compared with Group 2 (p,0.001), patients with ACR (p,0.001), patients with ATN (p,0.001) and patients with drug toxicity (p,0.001). Using 2610 23 mm 2 s 21 as a cut-off, there was no overlap between the ADC values of patients with normal graft function and those with ATN. Both ACR and ATN had a low ADC value, but on the ADC map the kidney in cases of ATN appears heterogeneous with a characteristic mosaic pattern resembling the Tiger skin. There was no significant T 2 W morphological difference between the two groups. Conclusion: These results show how DW MRI is a promising new technique for the diagnosis of acute renal transplant dysfunction.

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Hemodynamic Effect of Iodinated High-Viscosity Contrast Medium in the Rat Kidney

Abstract: This preliminary experience in rats shows that dynamic diffusion-weighted MRI can be used to study noninvasively the in vivo renal hemodynamic response after injection of iodinated contrast.

Cited by 26 publications

References 28 publications

Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion‐weighted MRI

Time course study on the effects of iodinated contrast medium on intrarenal water transport function using diffusion‐weighted MRI

Diffusion-weighted MRI in the evaluation of renal lesions: preliminary results

Role of diffusion-weighted MRI in diagnosis of acute renal allograft dysfunction: a prospective preliminary study

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