Hemodynamic determinants of maximum negative dP-dt and periods of diastole

Weisfeldt, M. L.; He, Song; Frederiksen, James W.; Rubenstein, J J; Pohost, G M; Beierholm, E. A.; Bello, A; Wm, Daggett

doi:10.1152/ajplegacy.1974.227.3.613

Cited by 157 publications

(67 citation statements)

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“…during periods of induced ischemia, that was maintained at zero. The effects on myocardial contractility and left ventricle relaxation was measured by calculating the first positive temporal derivative (+dP/dt max ) [12] and negative (-dP/dt max ) [13] of the left ventricular pressure, from measures obtained from the ventricular pressure curves, according to the method described by Gottschall [14].…”

Section: Methodsmentioning

confidence: 99%

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Pinheiro¹,

Fiorelli²,

Gomes³

2009

Rev Bras Cir Cardiovasc

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Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratosEffects of ischemic postconditioning on left ventricular function of isolated rat hearts Abstract Objective: To assess the effects of ischemic postconditioning on left ventricular function in isolated rat hearts.Methods: Twenty-four Wistar rats were used. These hearts underwent perfusion by modified LANGERDORFF method and distributed into three groups: GI -control (n=8); GII -three cycles of postconditioning of 10/10s (n=8); GIIIthree cycles of postconditioning of 30/30s (n=8). After a 15min stabilization period, all hearts underwent 20min of global ischemia following 20min of reperfusion. In the times 0 (control), 5, 10, 15 and 20min of reperfusion, the heart rate (HR), the coronary flow (CoF), the systolic pressure, the (+dP/dt max) contractility and (-dP/dt max) velocity of relaxation were measured. Data were analyzed by ANOVA method followed by Tukey's test for differences between groups and P < 0.05 was considered significant. Rev Bras Cir Cardiovasc 2009; 24(1): 31-37

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Section: Methodsmentioning

confidence: 99%

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Pinheiro¹,

Fiorelli²,

Gomes³

2009

Rev Bras Cir Cardiovasc

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“…25) The time of the maximum rate of LV pressure fall (ie, the minimum timederivative of pressure (dP/dt min )) has been employed as an index of activity of the relaxation system. 26) dP/dt min was first defined as the starting point of the relaxation pressure curve for monoexponential fitting, 14) and subsequently monoexponential fitting from the start of dP/dt min has been used widely. 16,17,27) However, it is evident that there is a considerable gap between the best-fit monoexponential curve and the actual relaxation curve near dP/dt min .…”

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confidence: 99%

Superior Logistic Model for Decay of Ca2+ Transient and Isometric Relaxation Force Curve in Rabbit and Mouse Papillary Muscles

et al. 2007

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SUMMARYA decrease in myocardial intracellular calcium concentration ([Ca 2+ ] i ) precedes relaxation, and a monoexponential function is typically used for fitting the decay of the Ca 2+ transient. However, a logistic function has been shown to be a better fit for the relaxation force curve, compared to the conventional monoexponential function. In the present study, we compared the logistic and monoexponential functions for fitting the [Ca 2+ ] i declines, which were measured using the aequorin method, and isometric relaxation force curves at 4 different onsets: the minimum time ] i /dt min and dF/dt min were significantly smaller than the changes in the normalized monoexponential time constants. The ratio of the logistic relaxation force time constant relative to the logistic [Ca 2+ ] i decline time constant was significantly smaller in mouse than in rabbit. We conclude that the logistic function more reliably characterizes the [Ca 2+ ] i decline and relaxation force curve at any onset, irrespective of animal species. Simultaneous analyses using the logistic model for decay of the Ca 2+ transient and myocardial lusitropism might be a useful strategy for analysis of species-specific myocardial calcium handling. (Int Heart J 2007; 48: 215-232)

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“…Many factors influence the left ventricle in diastole, but the completeness of ventricular relaxation and external diastolic constraints of the ventricle are among the most important.5' [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] With regard to external constraints, attention has focused on the influence of the pericardium, right ventricular loading, and coronary perfusion pressure" [18][19][20][21][22][23][24][25]30 on left ventricular diastolic compliance. Glantz and Parmley have suggested that during ischemia induced by atrial pacing, increased rightsided volume and pressure cause the left ventricular diastolic pressure-volume curve to shift upward as a result of "direct mechanical coupling between the two ventricles," enhanced by the intact pericardium.5 They cite data of Weiss et al 26 as being inconsistent with the concept that impaired relaxation is playing a major role in causing the altered left ventricular diastolic pressures, as had been suggested by several investigators.4 ' 6, 12, 13, 15, 16 The present study was designed to examine the role of altered right ventricular loading and pericardial influences on the increased left ventricular diastolic pressure during angina.…”

mentioning

confidence: 99%

Factors contributing to altered left ventricular diastolic properties during angina pectoris.

Mann¹,

Goldberg²,

Mudge³

et al. 1979

Circulation

235

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Hemodynamic determinants of maximum negative dP-dt and periods of diastole

Cited by 157 publications

References 0 publications

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Efeitos do pós-condicionamento isquêmico na função ventricular esquerda de corações isolados de ratos

Superior Logistic Model for Decay of Ca2+ Transient and Isometric Relaxation Force Curve in Rabbit and Mouse Papillary Muscles

Factors contributing to altered left ventricular diastolic properties during angina pectoris.

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